Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic; Tommie W. Redding; Andrew V. Schally

doi:10.1007/BF02934909

Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic, Tommie W. Redding, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe^1,2, d-Trp³, d-Arg⁶, d-Ala¹⁰-LH-RH. Incorporation of³²P from³²P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

Original language	English (US)
Pages (from-to)	243-247
Number of pages	5
Journal	Medical Oncology and Tumor Pharmacotherapy
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/BF02934909
State	Published - Dec 1985
Externally published	Yes

Keywords

P incorporation
LH-RH treatment
MT-W9A mammary tumor

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)
Oncology
Medicine(all)

Access to Document

10.1007/BF02934909

Cite this

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title = "Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs",

abstract = "We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.",

keywords = "P incorporation, LH-RH treatment, MT-W9A mammary tumor",

author = "Georges Cehovic and Redding, {Tommie W.} and Schally, {Andrew V.}",

year = "1985",

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doi = "10.1007/BF02934909",

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volume = "2",

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AU - Cehovic, Georges

AU - Redding, Tommie W.

AU - Schally, Andrew V.

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N2 - We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

AB - We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

KW - P incorporation

KW - LH-RH treatment

KW - MT-W9A mammary tumor

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