Abstract
We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 243-247 |
| Number of pages | 5 |
| Journal | Medical Oncology and Tumor Pharmacotherapy |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 1985 |
| Externally published | Yes |
Keywords
- P incorporation
- LH-RH treatment
- MT-W9A mammary tumor
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology (medical)
- Oncology
- Medicine(all)
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Cehovic, G., Redding, T. W., & Schally, A. V. (1985). Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs. Medical Oncology and Tumor Pharmacotherapy, 2(4), 243-247. https://doi.org/10.1007/BF02934909