Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic; Tommie W. Redding; Andrew V. Schally

doi:10.1007/BF02934909

Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic, Tommie W. Redding, Andrew V. Schally

Pathology

Research output: Contribution to journal › Article

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe^1,2, d-Trp³, d-Arg⁶, d-Ala¹⁰-LH-RH. Incorporation of³²P from³²P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

Original language	English (US)
Pages (from-to)	243-247
Number of pages	5
Journal	Medical Oncology and Tumor Pharmacotherapy
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/BF02934909
State	Published - Dec 1 1985

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Keywords

P incorporation
LH-RH treatment
MT-W9A mammary tumor

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)
Oncology
Medicine(all)

Cite this

Cehovic, G., Redding, T. W., & Schally, A. V. (1985). Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs. Medical Oncology and Tumor Pharmacotherapy, 2(4), 243-247. https://doi.org/10.1007/BF02934909

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10.1007/BF02934909