Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic, Tommie W. Redding, Andrew V. Schally

Research output: Contribution to journalArticle

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

Original languageEnglish (US)
Pages (from-to)243-247
Number of pages5
JournalMedical Oncology and Tumor Pharmacotherapy
Volume2
Issue number4
DOIs
StatePublished - Dec 1 1985

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Keywords

  • P incorporation
  • LH-RH treatment
  • MT-W9A mammary tumor

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)
  • Oncology
  • Medicine(all)

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