Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic; Tommie W. Redding; Andrew V Schally

doi:10.1007/BF02934909

Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic, Tommie W. Redding, Andrew V Schally

Research output: Contribution to journal › Article

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe^1,2, d-Trp³, d-Arg⁶, d-Ala¹⁰-LH-RH. Incorporation of³²P from³²P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Medical Oncology and Tumor Pharmacotherapy
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/BF02934909
State	Published - Dec 1 1985
Externally published	Yes

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Gonadotropin-Releasing Hormone

Breast Neoplasms

Phosphorylation

Neoplasms

Adenosine Triphosphate

Hormones

Proteins

Keywords

P incorporation
LH-RH treatment
MT-W9A mammary tumor

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)
Oncology
Medicine(all)

Cite this

Cehovic, G., Redding, T. W., & Schally, A. V. (1985). Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs. Medical Oncology and Tumor Pharmacotherapy, 2(4), 243-247. https://doi.org/10.1007/BF02934909

Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs. / Cehovic, Georges; Redding, Tommie W.; Schally, Andrew V.

In: Medical Oncology and Tumor Pharmacotherapy, Vol. 2, No. 4, 01.12.1985, p. 243-247.

Research output: Contribution to journal › Article

Cehovic, G, Redding, TW & Schally, AV 1985, 'Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs', Medical Oncology and Tumor Pharmacotherapy, vol. 2, no. 4, pp. 243-247. https://doi.org/10.1007/BF02934909

Cehovic G, Redding TW, Schally AV. Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs. Medical Oncology and Tumor Pharmacotherapy. 1985 Dec 1;2(4):243-247. https://doi.org/10.1007/BF02934909

Cehovic, Georges ; Redding, Tommie W. ; Schally, Andrew V. / Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs. In: Medical Oncology and Tumor Pharmacotherapy. 1985 ; Vol. 2, No. 4. pp. 243-247.

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