Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic; Tommie W. Redding; Andrew V. Schally

doi:10.1007/BF02934909

Changes in the³²P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

Georges Cehovic, Tommie W. Redding, Andrew V. Schally

Research output: Contribution to journal › Article › peer-review

Abstract

We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe^1,2, d-Trp³, d-Arg⁶, d-Ala¹⁰-LH-RH. Incorporation of³²P from³²P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

Original language	English (US)
Pages (from-to)	243-247
Number of pages	5
Journal	Medical Oncology and Tumor Pharmacotherapy
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/BF02934909
State	Published - Dec 1 1985
Externally published	Yes

Keywords

P incorporation
LH-RH treatment
MT-W9A mammary tumor

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)
Oncology
Medicine(all)

Access to Document

10.1007/BF02934909

Fingerprint Dive into the research topics of 'Changes in the<sup>32</sup>P incorporation in rat mammary tumor after chronic administration of LH-RH analogs'. Together they form a unique fingerprint.

Cite this

@article{84694d00f7fe43f78bc28369566e4cf9,

title = "Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs",

abstract = "We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.",

keywords = "P incorporation, LH-RH treatment, MT-W9A mammary tumor",

author = "Georges Cehovic and Redding, {Tommie W.} and Schally, {Andrew V.}",

year = "1985",

month = dec,

day = "1",

doi = "10.1007/BF02934909",

language = "English (US)",

volume = "2",

pages = "243--247",

journal = "Medical Oncology",

issn = "1357-0560",

publisher = "Humana Press",

number = "4",

}

TY - JOUR

T1 - Changes in the32P incorporation in rat mammary tumor after chronic administration of LH-RH analogs

AU - Cehovic, Georges

AU - Redding, Tommie W.

AU - Schally, Andrew V.

PY - 1985/12/1

Y1 - 1985/12/1

N2 - We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

AB - We studied endogenous phosphorylation in rat transplantable MT/W9A hormone-dependent mammary tumors of untreated rats and of animals treated with LH-RH analogs, the agonist d-Trp-6-LH-RH and the antagonist N-Ac-d-p-Cl-Phe1,2, d-Trp3, d-Arg6, d-Ala10-LH-RH. Incorporation of32P from32P-ATP was reduced significantly in tumors of rats treated with agonistic and antagonistic analogs of LH-RH or ovariectomized. The inhibition of protein phosphorylation may be related to tumor regression.

KW - P incorporation

KW - LH-RH treatment

KW - MT-W9A mammary tumor

UR - http://www.scopus.com/inward/record.url?scp=0022270074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022270074&partnerID=8YFLogxK

U2 - 10.1007/BF02934909

DO - 10.1007/BF02934909

M3 - Article

C2 - 2935686

AN - SCOPUS:0022270074

VL - 2

SP - 243

EP - 247

JO - Medical Oncology

JF - Medical Oncology

SN - 1357-0560

IS - 4

ER -