Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress

Gretchen N. Neigh, Michael J. Owens, W. Robert Taylor, Charles Nemeroff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In addition to the neuronal and behavioral consequences of excess glucocorticoid exposure, the cerebrovascular system can also be adversely affected by stressors. This study determined that chronic stress in adulthood decreased the vascular area fraction of the hippocampus and increased the vascular area fraction of the amygdala. In addition, the data indicated that prenatal exposure to synthetic glucocorticoids modulated the effects of adult stress on vascular area fraction of the hippocampus and amygdala. These data indicate that in addition to the well-documented stress-induced changes in neurons and glia, cerebral vasculature is also altered by exposure to stressors.

Original languageEnglish
Pages (from-to)1100-1104
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume30
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Amygdala
Dexamethasone
Blood Vessels
Hippocampus
Glucocorticoids
Neuroglia
Neurons

Keywords

  • Angiogenesis
  • Anhedonia
  • Dexamethasone
  • Prenatal stress
  • Vascular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress. / Neigh, Gretchen N.; Owens, Michael J.; Taylor, W. Robert; Nemeroff, Charles.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 30, No. 6, 01.06.2010, p. 1100-1104.

Research output: Contribution to journalArticle

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