Changes in the sleep and waking EEGs of nondemented and demented elderly subjects

P. N. Prinz, E. R. Peskind, P. P. Vitaliano, M. A. Raskind, C. Eisdorfer, N. Zemcuznikov, C. J. Gerber

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

Sleep and waking EEGs from 11 healthy nondemented elderly men and from ten inpatients for whom the diagnosis was probable senile dementia of Alzheimer's type (SDAT) were monitored in the subjects' typical home or ward environments or in the sleep laboratory, according to their customary sleep schedules. Aged normal subjects (age range, 56-85 years) had less Stage 3 and Stage 4 sleep, less REM sleep, and more wakefulness than normally observed in young adults. Patients with SDAT (age range, 56-88 years) had even less Stage 3 sleep, no Stage 4 sleep, and very little REM sleep, and experienced fragmentation of their sleep, with frequent awakenings. These sleep variables were significantly different in the SDAT and control groups (MANOVA). Examination of the 24-hour plots of sleep/waking patterns revealed prominent fragmentation of the diurnal sleep/waking rhythm in SDAT patients, with frequent daytime napping and nighttime periods of wakefulness. In addition, significant group differences were observed for the EEG variable, dominant occipital frequency. More qualitative EEG variables (diffuse slowing, spindle activity, and paroxysmal discharges) also differed between groups. It is suggested that correlative neuropathologic data might provide an understanding of the basis for the sleep, EEG, and mental-function factors that undergo change in SDAT.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalJournal of the American Geriatrics Society
Volume30
Issue number2
StatePublished - Apr 26 1982
Externally publishedYes

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Electroencephalography
Sleep
Alzheimer Disease
Sleep Deprivation
Wakefulness
Sleep Stages
REM Sleep
Inpatients
Young Adult
Appointments and Schedules
Control Groups

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Prinz, P. N., Peskind, E. R., Vitaliano, P. P., Raskind, M. A., Eisdorfer, C., Zemcuznikov, N., & Gerber, C. J. (1982). Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. Journal of the American Geriatrics Society, 30(2), 86-93.

Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. / Prinz, P. N.; Peskind, E. R.; Vitaliano, P. P.; Raskind, M. A.; Eisdorfer, C.; Zemcuznikov, N.; Gerber, C. J.

In: Journal of the American Geriatrics Society, Vol. 30, No. 2, 26.04.1982, p. 86-93.

Research output: Contribution to journalArticle

Prinz, PN, Peskind, ER, Vitaliano, PP, Raskind, MA, Eisdorfer, C, Zemcuznikov, N & Gerber, CJ 1982, 'Changes in the sleep and waking EEGs of nondemented and demented elderly subjects', Journal of the American Geriatrics Society, vol. 30, no. 2, pp. 86-93.
Prinz PN, Peskind ER, Vitaliano PP, Raskind MA, Eisdorfer C, Zemcuznikov N et al. Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. Journal of the American Geriatrics Society. 1982 Apr 26;30(2):86-93.
Prinz, P. N. ; Peskind, E. R. ; Vitaliano, P. P. ; Raskind, M. A. ; Eisdorfer, C. ; Zemcuznikov, N. ; Gerber, C. J. / Changes in the sleep and waking EEGs of nondemented and demented elderly subjects. In: Journal of the American Geriatrics Society. 1982 ; Vol. 30, No. 2. pp. 86-93.
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