Changes in the pathogenesis and prevention of chronic lung disease of prematurity

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

With the increasing survival of extremely premature infants there is a large number of them who are developing chronic lung disease (CLD), but the severity of the lung damage is considerably less than that observed in the classic form of bronchopulmonary dysplasia (BPD). Because many of these infants have only a mild initial respiratory distress and therefore do not receive aggressive ventilation, it is clear that factors other than oxygen toxicity and barotrauma are involved in the pathogenesis of this new milder type of CLD. CLD results from the interaction of multiple factors that can injure the immature lung. For this reason the prevention must be based on the elimination of all the factors implicated in its pathogenesis. Clinical and epidemiological data strongly suggest that infections, either prenatal or nosocomial, and the presence of a patent ductus arteriosus (PDA) play a major role in the development of CLD in these infants. For this reason, efforts to prevent CLD in extremely low birth weight infants should include an aggressive approach to the prevention and treatment of prenatal and neonatal infections and an early closure of the PDA.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalAmerican Journal of Perinatology
Volume18
Issue number1
StatePublished - Apr 10 2001

Fingerprint

Lung Diseases
Chronic Disease
Patent Ductus Arteriosus
Extremely Premature Infants
Extremely Low Birth Weight Infant
Barotrauma
Bronchopulmonary Dysplasia
Lung
Infection
Ventilation
Oxygen
Therapeutics

Keywords

  • Bronchopulmonary dysplasia
  • Chronic lung disease
  • Inflammation
  • Lung injury
  • Mechanical ventilation
  • Patent ductus arteriosus
  • Prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Changes in the pathogenesis and prevention of chronic lung disease of prematurity. / Bancalari, Eduardo.

In: American Journal of Perinatology, Vol. 18, No. 1, 10.04.2001, p. 1-9.

Research output: Contribution to journalArticle

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