Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans

Luisa Guidi; Leonardo Antico; Carlo Bartoloni; Mario Costanzo; Andrea Errani; Augusto Tricerri; Marcello Vangeli; Gino Doria; Lucia Gatta; Cristina Goso; Laura Mancino; Daniela Frasca

doi:10.1016/S0047-6374(97)00144-9

Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans

Luisa Guidi, Leonardo Antico, Carlo Bartoloni, Mario Costanzo, Andrea Errani, Augusto Tricerri, Marcello Vangeli, Gino Doria, Lucia Gatta, Cristina Goso, Laura Mancino, Daniela Frasca

Microbiology & Immunology

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

The effects of aging on the activation of the cytoplasmic tyrosine protein kinase p56(lck) have been investigated in PBL from adult and elderly subjects upon activation with mitogens or different co-stimuli. Results show that the amount and phosphorylation of p56(lck) are reduced in PBL from elderly as compared to adult subjects. This finding suggests that alterations in p56(lck) may contribute to the age-associated loss of some T cell functions, such as proliferation and IL-2 production, which are found decreased in PBL from old individuals. However, p56(lck) seems irrelevant to the production of IFN-γ and IL-4 which were both found increased in the PBL from old subjects, as expected from the relative expansion of memory versus naive T cell subpopulations in aging.

Original language	English (US)
Pages (from-to)	177-186
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	102
Issue number	2-3
DOIs	https://doi.org/10.1016/S0047-6374(97)00144-9
State	Published - May 15 1998

Keywords

Aging
IL2
p56(lck)
Phosphorylation
T cell function

ASJC Scopus subject areas

Aging
Biochemistry
Developmental Biology
Developmental Neuroscience

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Guidi, L., Antico, L., Bartoloni, C., Costanzo, M., Errani, A., Tricerri, A., Vangeli, M., Doria, G., Gatta, L., Goso, C., Mancino, L., & Frasca, D. (1998). Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans. Mechanisms of Ageing and Development, 102(2-3), 177-186. https://doi.org/10.1016/S0047-6374(97)00144-9

Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans. / Guidi, Luisa; Antico, Leonardo; Bartoloni, Carlo; Costanzo, Mario; Errani, Andrea; Tricerri, Augusto; Vangeli, Marcello; Doria, Gino; Gatta, Lucia; Goso, Cristina; Mancino, Laura; Frasca, Daniela.

In: Mechanisms of Ageing and Development, Vol. 102, No. 2-3, 15.05.1998, p. 177-186.

Research output: Contribution to journal › Article

Guidi, Luisa ; Antico, Leonardo ; Bartoloni, Carlo ; Costanzo, Mario ; Errani, Andrea ; Tricerri, Augusto ; Vangeli, Marcello ; Doria, Gino ; Gatta, Lucia ; Goso, Cristina ; Mancino, Laura ; Frasca, Daniela. / Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans. In: Mechanisms of Ageing and Development. 1998 ; Vol. 102, No. 2-3. pp. 177-186.

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abstract = "The effects of aging on the activation of the cytoplasmic tyrosine protein kinase p56(lck) have been investigated in PBL from adult and elderly subjects upon activation with mitogens or different co-stimuli. Results show that the amount and phosphorylation of p56(lck) are reduced in PBL from elderly as compared to adult subjects. This finding suggests that alterations in p56(lck) may contribute to the age-associated loss of some T cell functions, such as proliferation and IL-2 production, which are found decreased in PBL from old individuals. However, p56(lck) seems irrelevant to the production of IFN-γ and IL-4 which were both found increased in the PBL from old subjects, as expected from the relative expansion of memory versus naive T cell subpopulations in aging.",

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