Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans

Luisa Guidi, Leonardo Antico, Carlo Bartoloni, Mario Costanzo, Andrea Errani, Augusto Tricerri, Marcello Vangeli, Gino Doria, Lucia Gatta, Cristina Goso, Laura Mancino, Daniela Frasca

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The effects of aging on the activation of the cytoplasmic tyrosine protein kinase p56(lck) have been investigated in PBL from adult and elderly subjects upon activation with mitogens or different co-stimuli. Results show that the amount and phosphorylation of p56(lck) are reduced in PBL from elderly as compared to adult subjects. This finding suggests that alterations in p56(lck) may contribute to the age-associated loss of some T cell functions, such as proliferation and IL-2 production, which are found decreased in PBL from old individuals. However, p56(lck) seems irrelevant to the production of IFN-γ and IL-4 which were both found increased in the PBL from old subjects, as expected from the relative expansion of memory versus naive T cell subpopulations in aging.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalMechanisms of Ageing and Development
Volume102
Issue number2-3
DOIs
StatePublished - May 15 1998

Keywords

  • Aging
  • IL2
  • p56(lck)
  • Phosphorylation
  • T cell function

ASJC Scopus subject areas

  • Aging
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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    Guidi, L., Antico, L., Bartoloni, C., Costanzo, M., Errani, A., Tricerri, A., Vangeli, M., Doria, G., Gatta, L., Goso, C., Mancino, L., & Frasca, D. (1998). Changes in the amount and level of phosphorylation of p56(lck) in PBL from aging humans. Mechanisms of Ageing and Development, 102(2-3), 177-186. https://doi.org/10.1016/S0047-6374(97)00144-9