Changes in prostate cancer grading

Including a new patient-centric grading system

Oleksandr Kryvenko, Jonathan I. Epstein

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The first structured approach to grade prostate cancer based on the underlying histological architecture was developed by Donald Gleason who in 1966 proposed a morphologic classification of prostate cancer and in 1974 demonstrated its clinical significance based on prostate cancer-specific death. Contemporarily referred to as the Gleason grading system, it has gained worldwide recognition allowing a more individualized approach to patients with prostate cancer. In 2005, the International Society of Urologic Pathology (ISUP) made the first revisions to the grading system. Subsequently, based on the new discoveries in pathologic and clinical aspects of prostate cancer, as well as the changing nature of the prostate cancer in part due to a robust screening, there was a need for experts to re-visit the approach to grade prostate cancer. In November 2014, the ISUP experts and clinical leaders in prostate cancer from 17 countries conducted a consensus conference in Chicago, IL, USA. The consensus conference defined various grade patterns and proposed the adoption of a new grading system of prostate cancer. Herein, we describe the background and rationale for the changes and provide guidelines to their clinical implementation. Prostate 76:427-433, 2016.

Original languageEnglish (US)
Pages (from-to)427-433
Number of pages7
JournalProstate
Volume76
Issue number5
DOIs
StatePublished - Apr 1 2016

Fingerprint

Prostatic Neoplasms
Clinical Pathology
Neoplasm Grading
Prostate
Guidelines
Pathology

Keywords

  • gleason grade
  • gleason score
  • grade group
  • new
  • prostate cancer

ASJC Scopus subject areas

  • Urology
  • Oncology

Cite this

Changes in prostate cancer grading : Including a new patient-centric grading system. / Kryvenko, Oleksandr; Epstein, Jonathan I.

In: Prostate, Vol. 76, No. 5, 01.04.2016, p. 427-433.

Research output: Contribution to journalArticle

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