Changes in ocular response analyzer parameters after LASIK

Shihao Chen, Ding Chen, Jianhua Wang, Fan Lu, Qinmei Wang, Jia Qu

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

PURPOSE: To investigate changes in Ocular Response Analyzer parameters after myopic LASIK. METHODS: Thirty myopic patients (60 eyes) undergoing bilateral LASIK were studied prospectively. Corneal hysteresis, corneal resistance factor, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) measurements were obtained with the Ocular Response Analyzer before and after LASIK. Central corneal thickness and corneal fl ap thickness were also measured with optical coherence tomography. RESULTS: Compared with preoperative baseline values, corneal hysteresis, corneal resistance factor, IOPg, IOPcc, and central corneal thickness decreased postoperatively (P<.01). Corneal hysteresis (CH), corneal resistance factor (CRF), IOPg, IOPcc, and central corneal thickness (CCT) increased between 10 days and 3 months (post-hoc, P<.05). (The differences between the preoperative values and those at 3 months postoperatively are denoted by Δ.) The correlation of the ablation depth was stronger for ΔCRF (r=0.457) than for ΔCH (r=0.271). ΔCH was negatively correlated to flap thickness (r=-0.361) and the ratio of fl ap thickness to preoperative central corneal thickness (r=-0.442) whereas ΔCRF was not. ΔCH was positively correlated with ΔIOPcc, and ΔCRF was positively correlated with ΔIOPg. ΔIOPg was positively correlated with ΔCCT whereas ΔIOPcc was not. CONCLUSIONS: Corneal biomechanical properties measured by corneal hysteresis and corneal resistance factor were decreased at 10 days after LASIK. Minimal recovery (approximately 10% of the changes) was achieved by 3 months. The changes in biomechanical properties may affect IOP measurement.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalJournal of Refractive Surgery
Volume26
Issue number4
DOIs
StatePublished - Apr 1 2010

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Laser In Situ Keratomileusis
R Factors
Optical Coherence Tomography
Intraocular Pressure

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Changes in ocular response analyzer parameters after LASIK. / Chen, Shihao; Chen, Ding; Wang, Jianhua; Lu, Fan; Wang, Qinmei; Qu, Jia.

In: Journal of Refractive Surgery, Vol. 26, No. 4, 01.04.2010, p. 279-288.

Research output: Contribution to journalArticle

Chen, Shihao ; Chen, Ding ; Wang, Jianhua ; Lu, Fan ; Wang, Qinmei ; Qu, Jia. / Changes in ocular response analyzer parameters after LASIK. In: Journal of Refractive Surgery. 2010 ; Vol. 26, No. 4. pp. 279-288.
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N2 - PURPOSE: To investigate changes in Ocular Response Analyzer parameters after myopic LASIK. METHODS: Thirty myopic patients (60 eyes) undergoing bilateral LASIK were studied prospectively. Corneal hysteresis, corneal resistance factor, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) measurements were obtained with the Ocular Response Analyzer before and after LASIK. Central corneal thickness and corneal fl ap thickness were also measured with optical coherence tomography. RESULTS: Compared with preoperative baseline values, corneal hysteresis, corneal resistance factor, IOPg, IOPcc, and central corneal thickness decreased postoperatively (P<.01). Corneal hysteresis (CH), corneal resistance factor (CRF), IOPg, IOPcc, and central corneal thickness (CCT) increased between 10 days and 3 months (post-hoc, P<.05). (The differences between the preoperative values and those at 3 months postoperatively are denoted by Δ.) The correlation of the ablation depth was stronger for ΔCRF (r=0.457) than for ΔCH (r=0.271). ΔCH was negatively correlated to flap thickness (r=-0.361) and the ratio of fl ap thickness to preoperative central corneal thickness (r=-0.442) whereas ΔCRF was not. ΔCH was positively correlated with ΔIOPcc, and ΔCRF was positively correlated with ΔIOPg. ΔIOPg was positively correlated with ΔCCT whereas ΔIOPcc was not. CONCLUSIONS: Corneal biomechanical properties measured by corneal hysteresis and corneal resistance factor were decreased at 10 days after LASIK. Minimal recovery (approximately 10% of the changes) was achieved by 3 months. The changes in biomechanical properties may affect IOP measurement.

AB - PURPOSE: To investigate changes in Ocular Response Analyzer parameters after myopic LASIK. METHODS: Thirty myopic patients (60 eyes) undergoing bilateral LASIK were studied prospectively. Corneal hysteresis, corneal resistance factor, Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) measurements were obtained with the Ocular Response Analyzer before and after LASIK. Central corneal thickness and corneal fl ap thickness were also measured with optical coherence tomography. RESULTS: Compared with preoperative baseline values, corneal hysteresis, corneal resistance factor, IOPg, IOPcc, and central corneal thickness decreased postoperatively (P<.01). Corneal hysteresis (CH), corneal resistance factor (CRF), IOPg, IOPcc, and central corneal thickness (CCT) increased between 10 days and 3 months (post-hoc, P<.05). (The differences between the preoperative values and those at 3 months postoperatively are denoted by Δ.) The correlation of the ablation depth was stronger for ΔCRF (r=0.457) than for ΔCH (r=0.271). ΔCH was negatively correlated to flap thickness (r=-0.361) and the ratio of fl ap thickness to preoperative central corneal thickness (r=-0.442) whereas ΔCRF was not. ΔCH was positively correlated with ΔIOPcc, and ΔCRF was positively correlated with ΔIOPg. ΔIOPg was positively correlated with ΔCCT whereas ΔIOPcc was not. CONCLUSIONS: Corneal biomechanical properties measured by corneal hysteresis and corneal resistance factor were decreased at 10 days after LASIK. Minimal recovery (approximately 10% of the changes) was achieved by 3 months. The changes in biomechanical properties may affect IOP measurement.

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