Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher

Bianca Maceo Heilman, Fabrice Manns, Alberto De Castro, Heather Durkee, Esdras Arrieta Quintero, Susana Marcos, Jean-Marie A Parel

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

PURPOSE. The purpose of this study was to quantify accommodation-induced changes in the spherical aberration of cynomolgus monkey lenses. METHODS. Twenty-four lenses from 20 cynomolgus monkeys (Macaca fascicularis; 4.4-16.0 years of age; postmortem time 13.5±13.0 hours) were mounted in a lens stretcher. Lens spherical aberration was measured in the unstretched (accommodated) and stretched (relaxed) states with a laser ray tracing system that delivered 51 equally spaced parallel rays along 1 meridian of the lens over the central 6-mm optical zone. A camera mounted below the lens was used to measure the ray height at multiple positions along the optical axis. For each entrance ray, the change in ray height with axial position was fitted with a third-order polynomial. The effective paraxial focal length and Zernike spherical aberration coefficients corresponding to a 6-mm pupil diameter were extracted from the fitted values. RESULTS. The unstretched lens power decreased with age from 59.3±6 4.0 diopters (D) for young lenses to 45.7±6 3.1 D for older lenses. The unstretched lens shifted toward less negative spherical aberration with age, from -6.3±0.7 lm for young lenses to-5.0±0.5 lm for older lenses. The power and spherical aberration of lenses in the stretched state were independent of age, with values of 33.5±6 3.4 D and-2.6±0.5 lm, respectively. CONCLUSIONS. Spherical aberration is negative in cynomolgus monkey lenses and becomes more negative with accommodation. These results are in good agreement with the predicted values using computational ray tracing in a lens model with a reconstructed gradient refractive index. The spherical aberration of the unstretched lens becomes less negative with age.

Original languageEnglish (US)
Pages (from-to)1743-1750
Number of pages8
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number3
DOIs
StatePublished - 2015

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Crystalline Lens
Lenses
Haplorhini
Macaca fascicularis
Meridians
Refractometry
Pupil

Keywords

  • Crystalline lens
  • Laser ray tracing
  • Optics
  • Spherical aberration

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher. / Heilman, Bianca Maceo; Manns, Fabrice; De Castro, Alberto; Durkee, Heather; Arrieta Quintero, Esdras; Marcos, Susana; Parel, Jean-Marie A.

In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 3, 2015, p. 1743-1750.

Research output: Contribution to journalArticle

Heilman, Bianca Maceo ; Manns, Fabrice ; De Castro, Alberto ; Durkee, Heather ; Arrieta Quintero, Esdras ; Marcos, Susana ; Parel, Jean-Marie A. / Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher. In: Investigative Ophthalmology and Visual Science. 2015 ; Vol. 56, No. 3. pp. 1743-1750.
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T1 - Changes in monkey crystalline lens spherical aberration during simulated accommodation in a lens stretcher

AU - Heilman, Bianca Maceo

AU - Manns, Fabrice

AU - De Castro, Alberto

AU - Durkee, Heather

AU - Arrieta Quintero, Esdras

AU - Marcos, Susana

AU - Parel, Jean-Marie A

PY - 2015

Y1 - 2015

N2 - PURPOSE. The purpose of this study was to quantify accommodation-induced changes in the spherical aberration of cynomolgus monkey lenses. METHODS. Twenty-four lenses from 20 cynomolgus monkeys (Macaca fascicularis; 4.4-16.0 years of age; postmortem time 13.5±13.0 hours) were mounted in a lens stretcher. Lens spherical aberration was measured in the unstretched (accommodated) and stretched (relaxed) states with a laser ray tracing system that delivered 51 equally spaced parallel rays along 1 meridian of the lens over the central 6-mm optical zone. A camera mounted below the lens was used to measure the ray height at multiple positions along the optical axis. For each entrance ray, the change in ray height with axial position was fitted with a third-order polynomial. The effective paraxial focal length and Zernike spherical aberration coefficients corresponding to a 6-mm pupil diameter were extracted from the fitted values. RESULTS. The unstretched lens power decreased with age from 59.3±6 4.0 diopters (D) for young lenses to 45.7±6 3.1 D for older lenses. The unstretched lens shifted toward less negative spherical aberration with age, from -6.3±0.7 lm for young lenses to-5.0±0.5 lm for older lenses. The power and spherical aberration of lenses in the stretched state were independent of age, with values of 33.5±6 3.4 D and-2.6±0.5 lm, respectively. CONCLUSIONS. Spherical aberration is negative in cynomolgus monkey lenses and becomes more negative with accommodation. These results are in good agreement with the predicted values using computational ray tracing in a lens model with a reconstructed gradient refractive index. The spherical aberration of the unstretched lens becomes less negative with age.

AB - PURPOSE. The purpose of this study was to quantify accommodation-induced changes in the spherical aberration of cynomolgus monkey lenses. METHODS. Twenty-four lenses from 20 cynomolgus monkeys (Macaca fascicularis; 4.4-16.0 years of age; postmortem time 13.5±13.0 hours) were mounted in a lens stretcher. Lens spherical aberration was measured in the unstretched (accommodated) and stretched (relaxed) states with a laser ray tracing system that delivered 51 equally spaced parallel rays along 1 meridian of the lens over the central 6-mm optical zone. A camera mounted below the lens was used to measure the ray height at multiple positions along the optical axis. For each entrance ray, the change in ray height with axial position was fitted with a third-order polynomial. The effective paraxial focal length and Zernike spherical aberration coefficients corresponding to a 6-mm pupil diameter were extracted from the fitted values. RESULTS. The unstretched lens power decreased with age from 59.3±6 4.0 diopters (D) for young lenses to 45.7±6 3.1 D for older lenses. The unstretched lens shifted toward less negative spherical aberration with age, from -6.3±0.7 lm for young lenses to-5.0±0.5 lm for older lenses. The power and spherical aberration of lenses in the stretched state were independent of age, with values of 33.5±6 3.4 D and-2.6±0.5 lm, respectively. CONCLUSIONS. Spherical aberration is negative in cynomolgus monkey lenses and becomes more negative with accommodation. These results are in good agreement with the predicted values using computational ray tracing in a lens model with a reconstructed gradient refractive index. The spherical aberration of the unstretched lens becomes less negative with age.

KW - Crystalline lens

KW - Laser ray tracing

KW - Optics

KW - Spherical aberration

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