Changes in magnetic resonance imaging and sex behavior after 6-OHDA injection in the medial preoptic area

Jasbeer Kaur Dhawan, Velayudhan Mohan Kumar, Varan Govind, Partha Raghunathan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Magnetic resonance imaging (MRI) of the brains of male rats was done before and after destroying the catechol-amine (CA) fibers by local application of 6-hydroxydopamine (6-OHDA) in the medial preoptic area (mPOA). The male sexual behavior was also assessed before and after injection of this toxic drug. The administration of 6-OHDA (8 μg) resulted in highly variable lesions, as shown by MRI and confirmed by histological examination. A hyperintense area was visible either on one or on both sides, about 1-3 h after the administration of the drug. Postmortem histofluorescence showed destruction of CA fibers in the mPOA on those sides that showed hyperintense areas in the MRI. No CA fiber destruction was seen in those rats that had shown no change in MRI after 6-OHDA injection. There was a transient reduction in sex drive score in all the 6-OHDA-treated rats. The present findings point out a correlation between the MRI changes and CA fiber destruction, whereas the transient reduction in the sexual behavior was not related to these changes. It is suggested that some biochemical events related to 6-OHDA destruction of CA fibers may have been responsible for the hyperintensity seen in the MRI.

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalBrain Research Bulletin
Volume45
Issue number3
DOIs
StatePublished - Feb 1998
Externally publishedYes

Fingerprint

Preoptic Area
Oxidopamine
Sexual Behavior
Amines
Magnetic Resonance Imaging
Injections
Poisons
Pharmaceutical Preparations
catechol
Brain

Keywords

  • Catecholaminergic fibers
  • Hypothalamus
  • Lesion
  • Neuroimaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Changes in magnetic resonance imaging and sex behavior after 6-OHDA injection in the medial preoptic area. / Dhawan, Jasbeer Kaur; Kumar, Velayudhan Mohan; Govind, Varan; Raghunathan, Partha.

In: Brain Research Bulletin, Vol. 45, No. 3, 02.1998, p. 333-339.

Research output: Contribution to journalArticle

Dhawan, Jasbeer Kaur ; Kumar, Velayudhan Mohan ; Govind, Varan ; Raghunathan, Partha. / Changes in magnetic resonance imaging and sex behavior after 6-OHDA injection in the medial preoptic area. In: Brain Research Bulletin. 1998 ; Vol. 45, No. 3. pp. 333-339.
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