Abstract
Background: Left ventricular (LV) hypertrophy is an independent risk factor for cardiovascular outcomes. There are limited data about modifiable factors associated with progression of LV hypertrophy in older adults. Our objective is to describe the changes in LV mass and geometry over time in a predominantly older multiethnic cohort and to identify possible predictors of changes over time. Methods: We analyzed data from participants in the Northern Manhattan Study who underwent serial echocardiographic studies, comparing the baseline and the most recent echocardiograms. We recorded changes in LV mass and geometry and correlated them with baseline characteristics using linear regression models. Results: There were 826 participants (mean age, 64.2 ± 8.0 years) included in the analysis (time between measurements, 8.5 ± 2.7 years). Overall, LV mass index increased from 45.0 ± 12.7 to 50.3 ± 14.6 g/m2.7 (P <.001). There were 548 participants (66.3%) with LV mass increase; 258 individuals (31.2%) showed worsening LV geometry. Multivariable analysis showed that change in LV mass index was independently associated with baseline LV mass index (β estimate, −17.000 [standard error, 1.508]; P <.001), hypertension (2.094 [0.816], P =.011), body mass index (0.503 [0.088], P <.001), and waist-to-hip ratio (1.031 [0.385], P =.008). Both waist-to-hip ratio and waist-to-height ratio remained significantly associated with LV mass increase even after adjusting for body mass index (P =.008 and P =.036, respectively). Conclusions: Regardless of race/ethnicity, LV mass progressed over time in older adults. We also observed that worsening geometry was frequent. Assessment of central obesity in the older population is important because indicators of central obesity add prognostic value over body mass index for the risk of LV mass increase.
| Original language | English (US) |
|---|---|
| Journal | Journal of the American Society of Echocardiography |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Cardiac prevention
- Cardiac risk factors
- Epidemiology
- Hispanic population
- Longitudinal study
- Obesity
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Cardiology and Cardiovascular Medicine
Cite this
Changes in Left Ventricular Mass and Geometry in the Older Adults : Role of Body Mass and Central Obesity. / Lee, Tetz C.; Jin, Zhezhen; Homma, Shunichi; Nakanishi, Koki; Elkind, Mitchell S.V.; Rundek, Tatjana; Tugcu, Aylin; Matsumoto, Kenji; Sacco, Ralph L; Di Tullio, Marco R.
In: Journal of the American Society of Echocardiography, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in Left Ventricular Mass and Geometry in the Older Adults
T2 - Role of Body Mass and Central Obesity
AU - Lee, Tetz C.
AU - Jin, Zhezhen
AU - Homma, Shunichi
AU - Nakanishi, Koki
AU - Elkind, Mitchell S.V.
AU - Rundek, Tatjana
AU - Tugcu, Aylin
AU - Matsumoto, Kenji
AU - Sacco, Ralph L
AU - Di Tullio, Marco R.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Left ventricular (LV) hypertrophy is an independent risk factor for cardiovascular outcomes. There are limited data about modifiable factors associated with progression of LV hypertrophy in older adults. Our objective is to describe the changes in LV mass and geometry over time in a predominantly older multiethnic cohort and to identify possible predictors of changes over time. Methods: We analyzed data from participants in the Northern Manhattan Study who underwent serial echocardiographic studies, comparing the baseline and the most recent echocardiograms. We recorded changes in LV mass and geometry and correlated them with baseline characteristics using linear regression models. Results: There were 826 participants (mean age, 64.2 ± 8.0 years) included in the analysis (time between measurements, 8.5 ± 2.7 years). Overall, LV mass index increased from 45.0 ± 12.7 to 50.3 ± 14.6 g/m2.7 (P <.001). There were 548 participants (66.3%) with LV mass increase; 258 individuals (31.2%) showed worsening LV geometry. Multivariable analysis showed that change in LV mass index was independently associated with baseline LV mass index (β estimate, −17.000 [standard error, 1.508]; P <.001), hypertension (2.094 [0.816], P =.011), body mass index (0.503 [0.088], P <.001), and waist-to-hip ratio (1.031 [0.385], P =.008). Both waist-to-hip ratio and waist-to-height ratio remained significantly associated with LV mass increase even after adjusting for body mass index (P =.008 and P =.036, respectively). Conclusions: Regardless of race/ethnicity, LV mass progressed over time in older adults. We also observed that worsening geometry was frequent. Assessment of central obesity in the older population is important because indicators of central obesity add prognostic value over body mass index for the risk of LV mass increase.
AB - Background: Left ventricular (LV) hypertrophy is an independent risk factor for cardiovascular outcomes. There are limited data about modifiable factors associated with progression of LV hypertrophy in older adults. Our objective is to describe the changes in LV mass and geometry over time in a predominantly older multiethnic cohort and to identify possible predictors of changes over time. Methods: We analyzed data from participants in the Northern Manhattan Study who underwent serial echocardiographic studies, comparing the baseline and the most recent echocardiograms. We recorded changes in LV mass and geometry and correlated them with baseline characteristics using linear regression models. Results: There were 826 participants (mean age, 64.2 ± 8.0 years) included in the analysis (time between measurements, 8.5 ± 2.7 years). Overall, LV mass index increased from 45.0 ± 12.7 to 50.3 ± 14.6 g/m2.7 (P <.001). There were 548 participants (66.3%) with LV mass increase; 258 individuals (31.2%) showed worsening LV geometry. Multivariable analysis showed that change in LV mass index was independently associated with baseline LV mass index (β estimate, −17.000 [standard error, 1.508]; P <.001), hypertension (2.094 [0.816], P =.011), body mass index (0.503 [0.088], P <.001), and waist-to-hip ratio (1.031 [0.385], P =.008). Both waist-to-hip ratio and waist-to-height ratio remained significantly associated with LV mass increase even after adjusting for body mass index (P =.008 and P =.036, respectively). Conclusions: Regardless of race/ethnicity, LV mass progressed over time in older adults. We also observed that worsening geometry was frequent. Assessment of central obesity in the older population is important because indicators of central obesity add prognostic value over body mass index for the risk of LV mass increase.
KW - Cardiac prevention
KW - Cardiac risk factors
KW - Epidemiology
KW - Hispanic population
KW - Longitudinal study
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85068863529&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068863529&partnerID=8YFLogxK
U2 - 10.1016/j.echo.2019.05.018
DO - 10.1016/j.echo.2019.05.018
M3 - Article
C2 - 31311705
AN - SCOPUS:85068863529
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
SN - 0894-7317
ER -