Changes in extracellular glutamate concentration after acute subdural haematoma in the rat--evidence for an "excitotoxic" mechanism?

R. Bullock, S. Butcher, J. McCulloch

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Using a rat model of subdural haematoma which is associated with ischaemic damage in the ipsilateral hemisphere, we have measured cerebral blood flow and release of excitatory amino acids after the haematoma. A more than sevenfold rise in glutamate and aspartate, persisting for forty minutes occurred in the severely ischaemic cortex (CBF less than 5 ml 100 gm-1 min-1) and a threefold, sustained rise was seen in hippocampus, although CBF was preserved (85 ml/100 g/-1 min-1). Excitotoxic mechanisms may, therefore, be involved in the ischaemic damage associated with subdural haematoma.

Original languageEnglish (US)
Pages (from-to)274-276
Number of pages3
JournalActa neurochirurgica. Supplementum
Volume51
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Changes in extracellular glutamate concentration after acute subdural haematoma in the rat--evidence for an "excitotoxic" mechanism?'. Together they form a unique fingerprint.

  • Cite this