Change overtime in neopterin (NPT) & beta-2 microglobuun (B-2M) in HIV-infected children followed in the nichd ivig cunical trial: Correlation between measures association with mortality risk

Savita G Pahwa, L. Mofenson, J. Korelitz, W. Meyer, K. Rich, J. Bethel, R. Nugent

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate levels of NPT & β-2M in stored samples from HlV-infected children with mild-moderate HIV disease prospective/ followed in the NICHD MG Clinical Trial. Methods: Blood was collected for central storage at entry & 3 month intervals during the trial. Frozen specimens from children with Ω13 samples available were retrieved and tested for NPT and β-2M. Changes during the study were calculated as difference (final-entry level) and slope (average monthly change). Mortality rates were calculated by grouping children into quartlies based on difference and slope in their NPT and β-2M levels. Results: Assay results were available from 712 β-2M specimens (mean level [S.E.] = 198 [0.05] mg/L) and 631 NPT specimens (mean level [5.E.] = 3.56 [0.16] ng/ml) from HO children who had been followed for 6-18 months (mean follow-up = 14.1 months). In multivariate regression models including treatment (MG or placebo), time on study, AZT use, TMP/SMX use, serious bacterial infections, age at entry and entry CD4 count only age was significantly associated with change in β-2M (increasing levels with increasing age); increase in NPT was associated with increasing age and lower entry CD4 count Values of β-2M and NPT at entry showed significant correlation (Pearson correlation coefficient r = 0.72): a lesser but moderate correlation was seen for change ever time in the two measures (difference final-entry level): for β-2M mortality rate by quartile were 2.9%, 11.4%, 2.9%, 25.7%, respectively (x2 for trend = 6.5. p = 0.01): for NPT mortality rates were 0%, 111%, 5.9%, 25.0% (p = 0.005). A similar association was observed for slope (NPT, p = 0.01 ; β-2M, p = 0.04). Conclusions: A moderate correlation was observed between NPT and β-2M levels in infected children, and increases in both over time were associated with increased mortality risk.

Original languageEnglish
JournalPediatric AIDS and HIV Infection
Volume7
Issue number5
StatePublished - Dec 1 1996
Externally publishedYes

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Neopterin
HIV
Mortality
CD4 Lymphocyte Count
National Institute of Child Health and Human Development (U.S.)
Sulfamethoxazole Drug Combination Trimethoprim
Bacterial Infections
Placebos
Clinical Trials

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Change overtime in neopterin (NPT) & beta-2 microglobuun (B-2M) in HIV-infected children followed in the nichd ivig cunical trial : Correlation between measures association with mortality risk. / Pahwa, Savita G; Mofenson, L.; Korelitz, J.; Meyer, W.; Rich, K.; Bethel, J.; Nugent, R.

In: Pediatric AIDS and HIV Infection, Vol. 7, No. 5, 01.12.1996.

Research output: Contribution to journalArticle

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title = "Change overtime in neopterin (NPT) & beta-2 microglobuun (B-2M) in HIV-infected children followed in the nichd ivig cunical trial: Correlation between measures association with mortality risk",
abstract = "Objective: To evaluate levels of NPT & β-2M in stored samples from HlV-infected children with mild-moderate HIV disease prospective/ followed in the NICHD MG Clinical Trial. Methods: Blood was collected for central storage at entry & 3 month intervals during the trial. Frozen specimens from children with Ω13 samples available were retrieved and tested for NPT and β-2M. Changes during the study were calculated as difference (final-entry level) and slope (average monthly change). Mortality rates were calculated by grouping children into quartlies based on difference and slope in their NPT and β-2M levels. Results: Assay results were available from 712 β-2M specimens (mean level [S.E.] = 198 [0.05] mg/L) and 631 NPT specimens (mean level [5.E.] = 3.56 [0.16] ng/ml) from HO children who had been followed for 6-18 months (mean follow-up = 14.1 months). In multivariate regression models including treatment (MG or placebo), time on study, AZT use, TMP/SMX use, serious bacterial infections, age at entry and entry CD4 count only age was significantly associated with change in β-2M (increasing levels with increasing age); increase in NPT was associated with increasing age and lower entry CD4 count Values of β-2M and NPT at entry showed significant correlation (Pearson correlation coefficient r = 0.72): a lesser but moderate correlation was seen for change ever time in the two measures (difference final-entry level): for β-2M mortality rate by quartile were 2.9{\%}, 11.4{\%}, 2.9{\%}, 25.7{\%}, respectively (x2 for trend = 6.5. p = 0.01): for NPT mortality rates were 0{\%}, 111{\%}, 5.9{\%}, 25.0{\%} (p = 0.005). A similar association was observed for slope (NPT, p = 0.01 ; β-2M, p = 0.04). Conclusions: A moderate correlation was observed between NPT and β-2M levels in infected children, and increases in both over time were associated with increased mortality risk.",
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T1 - Change overtime in neopterin (NPT) & beta-2 microglobuun (B-2M) in HIV-infected children followed in the nichd ivig cunical trial

T2 - Correlation between measures association with mortality risk

AU - Pahwa, Savita G

AU - Mofenson, L.

AU - Korelitz, J.

AU - Meyer, W.

AU - Rich, K.

AU - Bethel, J.

AU - Nugent, R.

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