Change overtime in neopterin (NPT) & beta-2 microglobuun (B-2M) in HIV-infected children followed in the nichd ivig cunical trial: Correlation between measures association with mortality risk

Pahwa Savita, L. Mofenson, J. Korelitz, W. Meyer, K. Rich, J. Bethel, R. Nugent

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate levels of NPT & β-2M in stored samples from HlV-infected children with mild-moderate HIV disease prospective/ followed in the NICHD MG Clinical Trial. Methods: Blood was collected for central storage at entry & 3 month intervals during the trial. Frozen specimens from children with Ω13 samples available were retrieved and tested for NPT and β-2M. Changes during the study were calculated as difference (final-entry level) and slope (average monthly change). Mortality rates were calculated by grouping children into quartlies based on difference and slope in their NPT and β-2M levels. Results: Assay results were available from 712 β-2M specimens (mean level [S.E.] = 198 [0.05] mg/L) and 631 NPT specimens (mean level [5.E.] = 3.56 [0.16] ng/ml) from HO children who had been followed for 6-18 months (mean follow-up = 14.1 months). In multivariate regression models including treatment (MG or placebo), time on study, AZT use, TMP/SMX use, serious bacterial infections, age at entry and entry CD4 count only age was significantly associated with change in β-2M (increasing levels with increasing age); increase in NPT was associated with increasing age and lower entry CD4 count Values of β-2M and NPT at entry showed significant correlation (Pearson correlation coefficient r = 0.72): a lesser but moderate correlation was seen for change ever time in the two measures (difference final-entry level): for β-2M mortality rate by quartile were 2.9%, 11.4%, 2.9%, 25.7%, respectively (x2 for trend = 6.5. p = 0.01): for NPT mortality rates were 0%, 111%, 5.9%, 25.0% (p = 0.005). A similar association was observed for slope (NPT, p = 0.01 ; β-2M, p = 0.04). Conclusions: A moderate correlation was observed between NPT and β-2M levels in infected children, and increases in both over time were associated with increased mortality risk.

Original languageEnglish (US)
Number of pages1
JournalPediatric AIDS and HIV Infection
Volume7
Issue number5
StatePublished - Dec 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Change overtime in neopterin (NPT) & beta-2 microglobuun (B-2M) in HIV-infected children followed in the nichd ivig cunical trial: Correlation between measures association with mortality risk'. Together they form a unique fingerprint.

  • Cite this