Change in drusen area over time compared using spectral-domain optical coherence tomography and color fundus imaging

Giovanni Gregori, Zohar Yehoshua, Carlos Alexandre De Amorim Garcia Filho, Srinivas R. Sadda, Renata Portella Nunes, William J. Feuer, Philip J. Rosenfeld

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose. To investigate the relationship between drusen areas measured with color fundus images (CFIs) and those with spectral-domain optical coherence tomography (SDOCT).

Methods. Forty-two eyes from thirty patients with drusen in the absence of geographic atrophy were recruited to a prospective study. Digital color fundus images and SDOCT images were obtained at baseline and at follow-up visits at 3 and 6 months. Registered, matched circles centered on the fovea with diameters of 3 mm and 5 mm were identified on both CFIs and SDOCT images. Spectral-domain OCT drusen measurements were obtained using a commercially available proprietary algorithm. Drusen boundaries on CFIs were traced manually at the Doheny Eye Institute Image Reading Center.

Results. Mean square root drusen area (SQDA) measurements for the 3-mm circles on the SDOCT images were 1.451 mm at baseline and 1.464 mm at week 26, whereas the measurements on CFIs were 1.555 mm at baseline and 1.584 mm at week 26. Mean SQDA measurements from CFIs were larger than those from the SDOCT measurements at all time points (P ¼ 0.004 at baseline, P ¼ 0.003 at 26 weeks). Changes in SQDA over 26 weeks measured with SDOCT were not different from those measured with CFIs (mean difference ¼ 0.014 mm, P ¼ 0.5).

Conclusions. Spectral-domain OCT drusen area measurements were smaller than the measurements obtained from CFIs. However, there were no differences in the change in drusen area over time between the two imaging modalities. Spectral-domain OCT measurements were considerably more sensitive in assessing drusen area changes.

Original languageEnglish (US)
Pages (from-to)7662-7668
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number11
StatePublished - Oct 6 2014


  • Age-related macular degeneration
  • Color fundus photography
  • Drusen
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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