Abstract
Purpose: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN. Methods: Retrospective case series. Results: Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis. All patients had treatment complicated by multiple surgeries, recurrences, or advanced disease. The patients initially received medical treatment with topical interferon-alpha-2b (IFNα2b). However, all the patients had recurrences and required modification of treatment including topical 5-fluorouracil (5-FU). Conclusion: We report on three patients with a history of atopy whose OSSN presentation and course was challenging. Overall, our cases responded better to topical 5-fluorouracil compared to topical interferon-alpha-2b, but recurrences were common. These patients may benefit from more aggressive and long-term treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Ocular Immunology and Inflammation |
| DOIs | |
| State | Accepted/In press - Nov 24 2017 |
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Keywords
- 5- fluorouracil
- atopic disease
- Atopy
- interferon-alpha-2b
- ocular surface squamous neoplasia
- OSSN
ASJC Scopus subject areas
- Immunology and Allergy
- Ophthalmology
Cite this
Challenging Treatment of Ocular Surface Squamous Neoplasia in Patients with Atopic Disease. / Zhang, Lily; Mercado, Carolina; Galor, Anat; Holland, Edward J.; Wang, Gaofeng; Karp, Carol.
In: Ocular Immunology and Inflammation, 24.11.2017, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Challenging Treatment of Ocular Surface Squamous Neoplasia in Patients with Atopic Disease
AU - Zhang, Lily
AU - Mercado, Carolina
AU - Galor, Anat
AU - Holland, Edward J.
AU - Wang, Gaofeng
AU - Karp, Carol
PY - 2017/11/24
Y1 - 2017/11/24
N2 - Purpose: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN. Methods: Retrospective case series. Results: Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis. All patients had treatment complicated by multiple surgeries, recurrences, or advanced disease. The patients initially received medical treatment with topical interferon-alpha-2b (IFNα2b). However, all the patients had recurrences and required modification of treatment including topical 5-fluorouracil (5-FU). Conclusion: We report on three patients with a history of atopy whose OSSN presentation and course was challenging. Overall, our cases responded better to topical 5-fluorouracil compared to topical interferon-alpha-2b, but recurrences were common. These patients may benefit from more aggressive and long-term treatment.
AB - Purpose: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN. Methods: Retrospective case series. Results: Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis. All patients had treatment complicated by multiple surgeries, recurrences, or advanced disease. The patients initially received medical treatment with topical interferon-alpha-2b (IFNα2b). However, all the patients had recurrences and required modification of treatment including topical 5-fluorouracil (5-FU). Conclusion: We report on three patients with a history of atopy whose OSSN presentation and course was challenging. Overall, our cases responded better to topical 5-fluorouracil compared to topical interferon-alpha-2b, but recurrences were common. These patients may benefit from more aggressive and long-term treatment.
KW - 5- fluorouracil
KW - atopic disease
KW - Atopy
KW - interferon-alpha-2b
KW - ocular surface squamous neoplasia
KW - OSSN
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U2 - 10.1080/09273948.2017.1394470
DO - 10.1080/09273948.2017.1394470
M3 - Article
SP - 1
EP - 6
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
SN - 0927-3948
ER -