Challenging Treatment of Ocular Surface Squamous Neoplasia in Patients with Atopic Disease

Lily Zhang, Carolina Mercado, Anat Galor, Edward J. Holland, Gaofeng Wang, Carol L. Karp

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: Few studies have described ocular surface squamous neoplasia (OSSN) and its association with atopic diseases and there is no consensus on the course of OSSN in atopic patients. We thereby report three patients with atopy and OSSN. Methods: Retrospective case series. Results: Three male patients with mean age of 73 presented with OSSN and history of atopy treated with immunosuppressant therapy. Their histories included atopic dermatitis and keratoconjunctivitis. All patients had treatment complicated by multiple surgeries, recurrences, or advanced disease. The patients initially received medical treatment with topical interferon-alpha-2b (IFNα2b). However, all the patients had recurrences and required modification of treatment including topical 5-fluorouracil (5-FU). Conclusion: We report on three patients with a history of atopy whose OSSN presentation and course was challenging. Overall, our cases responded better to topical 5-fluorouracil compared to topical interferon-alpha-2b, but recurrences were common. These patients may benefit from more aggressive and long-term treatment.

Original languageEnglish (US)
Pages (from-to)288-293
Number of pages6
JournalOcular Immunology and Inflammation
Issue number2
StatePublished - Feb 17 2019


  • 5- fluorouracil
  • Atopy
  • OSSN
  • atopic disease
  • interferon-alpha-2b
  • ocular surface squamous neoplasia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology


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