Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis

J. C. Allen, William Sheremata, J. B R Cosgrove, K. Osterland, M. Shea

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45 Scopus citations

Abstract

Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cells is largest in the acute stage of a relapse (65%) and diminishes by the second week (41%). Conversely, the stable patients have a lower percentage of T cells (30%) and a relatively high percentage of nonreacting cells (66%). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.

Original languageEnglish
Pages (from-to)579-583
Number of pages5
JournalNeurology
Volume26
Issue number6 I
StatePublished - Dec 1 1976
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Allen, J. C., Sheremata, W., Cosgrove, J. B. R., Osterland, K., & Shea, M. (1976). Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. Neurology, 26(6 I), 579-583.