Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis

J. C. Allen, William Sheremata, J. B R Cosgrove, K. Osterland, M. Shea

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cells is largest in the acute stage of a relapse (65%) and diminishes by the second week (41%). Conversely, the stable patients have a lower percentage of T cells (30%) and a relatively high percentage of nonreacting cells (66%). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.

Original languageEnglish
Pages (from-to)579-583
Number of pages5
JournalNeurology
Volume26
Issue number6 I
StatePublished - Dec 1 1976
Externally publishedYes

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Multiple Sclerosis
Cerebrospinal Fluid
B-Lymphocytes
T-Lymphocytes
Recurrence
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Allen, J. C., Sheremata, W., Cosgrove, J. B. R., Osterland, K., & Shea, M. (1976). Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. Neurology, 26(6 I), 579-583.

Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. / Allen, J. C.; Sheremata, William; Cosgrove, J. B R; Osterland, K.; Shea, M.

In: Neurology, Vol. 26, No. 6 I, 01.12.1976, p. 579-583.

Research output: Contribution to journalArticle

Allen, JC, Sheremata, W, Cosgrove, JBR, Osterland, K & Shea, M 1976, 'Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis', Neurology, vol. 26, no. 6 I, pp. 579-583.
Allen JC, Sheremata W, Cosgrove JBR, Osterland K, Shea M. Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. Neurology. 1976 Dec 1;26(6 I):579-583.
Allen, J. C. ; Sheremata, William ; Cosgrove, J. B R ; Osterland, K. ; Shea, M. / Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. In: Neurology. 1976 ; Vol. 26, No. 6 I. pp. 579-583.
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