Abstract
Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cells is largest in the acute stage of a relapse (65%) and diminishes by the second week (41%). Conversely, the stable patients have a lower percentage of T cells (30%) and a relatively high percentage of nonreacting cells (66%). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 579-583 |
| Number of pages | 5 |
| Journal | Neurology |
| Volume | 26 |
| Issue number | 6 I |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. / Allen, J. C.; Sheremata, William; Cosgrove, J. B R; Osterland, K.; Shea, M.
In: Neurology, Vol. 26, No. 6 I, 01.12.1976, p. 579-583.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis
AU - Allen, J. C.
AU - Sheremata, William
AU - Cosgrove, J. B R
AU - Osterland, K.
AU - Shea, M.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cells is largest in the acute stage of a relapse (65%) and diminishes by the second week (41%). Conversely, the stable patients have a lower percentage of T cells (30%) and a relatively high percentage of nonreacting cells (66%). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.
AB - Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cells is largest in the acute stage of a relapse (65%) and diminishes by the second week (41%). Conversely, the stable patients have a lower percentage of T cells (30%) and a relatively high percentage of nonreacting cells (66%). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017062873&partnerID=8YFLogxK
M3 - Article
C2 - 1084494
AN - SCOPUS:0017062873
VL - 26
SP - 579
EP - 583
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 6 I
ER -