Abstract
Cerebrospinal fluid T and B lymphocyte populations were identified in 21 patients with relapsing and 10 patients with stable multiple sclerosis. The results indicate that the percentage of T cells is largest in the acute stage of a relapse (65%) and diminishes by the second week (41%). Conversely, the stable patients have a lower percentage of T cells (30%) and a relatively high percentage of nonreacting cells (66%). The proportion of T cells in the cerebrospinal fluid varies directly with the clinical activity of the disorder, further implicating cellular immune mechanisms in the pathogenesis of multiple sclerosis.
| Original language | English |
|---|---|
| Pages (from-to) | 579-583 |
| Number of pages | 5 |
| Journal | Neurology |
| Volume | 26 |
| Issue number | 6 I |
| State | Published - Dec 1 1976 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Allen, J. C., Sheremata, W., Cosgrove, J. B. R., Osterland, K., & Shea, M. (1976). Cerebrospinal fluid T and B lymphocyte kinetics related to exacerbations of multiple sclerosis. Neurology, 26(6 I), 579-583.