Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects

Emil F. Coccaro, Royce Lee, Michael J. Owens, Becky Kinkead, Charles Nemeroff

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Neurochemical studies have pointed to a modulatory role in human aggression for a variety of central neurotransmitters; some seem to play an inhibitory role, whereas others seem to play a facilitory role in the modulation of aggression. Laboratory animal studies of substance P suggest a facilitory role for this undecapeptide in the modulation of aggression, but no studies of substance P have yet been reported with regard to human aggression. Methods: Basal lumbar cerebrospinal fluid samples were obtained from 38 physically healthy subjects with personality disorder (PD) and substance P-like immunoreactivity was measured and correlated with measures of aggression and impulsivity. Results: The cerebrospinal fluid substance P-like immunoreactivity levels were directly correlated with a composite measure of aggression and, more specifically, with Buss-Durkee Aggression. No correlation was seen with any measure of impulsivity or of general dimensions of personality. Conclusions: These data suggest a direct relationship between central nervous system substance P containing neural circuits and aggression in human subjects. This finding adds to the complex picture of the central neuromodulatory role of impulsive aggression in human subjects.

Original languageEnglish
Pages (from-to)238-243
Number of pages6
JournalBiological Psychiatry
Volume72
Issue number3
DOIs
StatePublished - Aug 1 2012

Fingerprint

Substance P
Aggression
Personality
Cerebrospinal Fluid
Impulsive Behavior
Personality Disorders
Laboratory Animals
Neurotransmitter Agents
Healthy Volunteers
Central Nervous System

Keywords

  • Aggression
  • CSF
  • impulsivity
  • neurokinin-1
  • personality
  • substance P

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects. / Coccaro, Emil F.; Lee, Royce; Owens, Michael J.; Kinkead, Becky; Nemeroff, Charles.

In: Biological Psychiatry, Vol. 72, No. 3, 01.08.2012, p. 238-243.

Research output: Contribution to journalArticle

Coccaro, Emil F. ; Lee, Royce ; Owens, Michael J. ; Kinkead, Becky ; Nemeroff, Charles. / Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects. In: Biological Psychiatry. 2012 ; Vol. 72, No. 3. pp. 238-243.
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