Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment

Rajiv P. Sharma; Garth Bissette; Philip Janicak; John M. Davis; Charles B. Nemeroff

doi:10.1016/0920-9964(94)90099-X

Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment

Rajiv P. Sharma, Garth Bissette, Philip Janicak, John M. Davis, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.

Original language	English (US)
Pages (from-to)	173-177
Number of pages	5
Journal	Schizophrenia Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0920-9964(94)90099-X
State	Published - Sep 1994
Externally published	Yes

Keywords

Antipsychotic
Homovanillic acid
Somatostatin

ASJC Scopus subject areas

Psychology(all)
Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology

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title = "Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment",

abstract = "The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.",

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author = "Sharma, {Rajiv P.} and Garth Bissette and Philip Janicak and Davis, {John M.} and Nemeroff, {Charles B.}",

note = "Funding Information: This study was supported in part by NIMH MH-39415.",

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AU - Bissette, Garth

AU - Janicak, Philip

AU - Davis, John M.

AU - Nemeroff, Charles B.

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KW - Homovanillic acid

KW - Somatostatin

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