Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment

Rajiv P. Sharma; Garth Bissette; Philip Janicak; John M. Davis; Charles B. Nemeroff

doi:10.1016/0920-9964(94)90099-X

Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment

Rajiv P. Sharma, Garth Bissette, Philip Janicak, John M. Davis, Charles B. Nemeroff

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.

Original language	English (US)
Pages (from-to)	173-177
Number of pages	5
Journal	Schizophrenia Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.1016/0920-9964(94)90099-X
State	Published - Sep 1994
Externally published	Yes

Keywords

Antipsychotic
Homovanillic acid
Somatostatin

ASJC Scopus subject areas

Psychology(all)
Psychiatry and Mental health
Behavioral Neuroscience
Biological Psychiatry
Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0920-9964(94)90099-X

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title = "Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment",

abstract = "The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.",

keywords = "Antipsychotic, Homovanillic acid, Somatostatin",

author = "Sharma, {Rajiv P.} and Garth Bissette and Philip Janicak and Davis, {John M.} and Nemeroff, {Charles B.}",

note = "Funding Information: This study was supported in part by NIMH MH-39415.",

year = "1994",

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doi = "10.1016/0920-9964(94)90099-X",

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volume = "13",

pages = "173--177",

journal = "Schizophrenia Research",

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T1 - Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder

T2 - the effects of antipsychotic treatment

AU - Sharma, Rajiv P.

AU - Bissette, Garth

AU - Janicak, Philip

AU - Davis, John M.

AU - Nemeroff, Charles B.

N1 - Funding Information: This study was supported in part by NIMH MH-39415.

PY - 1994/9

Y1 - 1994/9

N2 - The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.

AB - The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.

KW - Antipsychotic

KW - Homovanillic acid

KW - Somatostatin

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AN - SCOPUS:0028021031

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JO - Schizophrenia Research

JF - Schizophrenia Research

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IS - 2

ER -

Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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