Abstract
The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 173-177 |
| Number of pages | 5 |
| Journal | Schizophrenia Research |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 1994 |
| Externally published | Yes |
Keywords
- Antipsychotic
- Homovanillic acid
- Somatostatin
ASJC Scopus subject areas
- Psychology(all)
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
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Cite this
Sharma, R. P., Bissette, G., Janicak, P., Davis, J. M., & Nemeroff, C. B. (1994). Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment. Schizophrenia Research, 13(2), 173-177. https://doi.org/10.1016/0920-9964(94)90099-X