Cerebrospinal fluid somatostatin concentrations in schizophrenia and schizoaffective disorder: the effects of antipsychotic treatment

Rajiv P. Sharma, Garth Bissette, Philip Janicak, John M. Davis, Charles B. Nemeroff

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The authors examined the effects of antipsychotic treatment on cerebrospinal fluid somatostatin like immunoreactivity (CSF SLI) in 14 schizophrenic and 3 schizoaffective patients. There was a modest but significant increase in CSF SLI in 13 out of the 14 schizophrenic patients. In addition, there was a significant positive correlation between duration of treatment and post-treatment CSF SLI concentrations. No differential response was noted in patients also treated with the anticholinergic benztropine.

Original languageEnglish (US)
Pages (from-to)173-177
Number of pages5
JournalSchizophrenia Research
Volume13
Issue number2
DOIs
StatePublished - Sep 1994
Externally publishedYes

Keywords

  • Antipsychotic
  • Homovanillic acid
  • Somatostatin

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology

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