Cerebrospinal-fluid neuropeptides: A biochemical subgrouping approach

C. M. Banki, L. Karmacsi, G. Bissette, Charles Nemeroff

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cerebrospinal-fluid (CSF) corticotropin-releasing hormone, somatostatin, and thyrotropin-releasing hormone were measured by specific radioimmunoassays in 257 hospitalized psychiatry patients suffering from dementia disorders (n = 85), schizophrenia (n = 104), and mood and anxiety disorders (n = 39). Neurological controls (n = 29) were also investigated. Since there were large overlaps of the peptide levels across the nosological groups we subjected the dataset to a three-dimensional normal mixture distribution analysis. We obtained four biochemically separable clusters. Dementia disorders, but not the others, were heterogeneously distributed in these clusters but after eliminating the effects of age and illness duration this difference disappeared. No single clinical, psychological, or background variable emerged as a prominent correlate of the neuropeptide clusters. It is concluded that although CSF neuropeptide concentrations in psychiatric patient populations appear to be separable into distinct, normally distributed subgroups this distinction does not coincide with present nosological classifications.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalNeuropsychobiology
Volume26
Issue number1-2
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Neuropeptides
Psychiatry
Cerebrospinal Fluid
Dementia
Thyrotropin-Releasing Hormone
Corticotropin-Releasing Hormone
Normal Distribution
Somatostatin
Anxiety Disorders
Mood Disorders
Radioimmunoassay
Schizophrenia
Psychology
Peptides
Population
Datasets

Keywords

  • Corticotropin-releasing hormone
  • Normal mixture distribution
  • Somatotropin
  • Thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

Cite this

Banki, C. M., Karmacsi, L., Bissette, G., & Nemeroff, C. (1992). Cerebrospinal-fluid neuropeptides: A biochemical subgrouping approach. Neuropsychobiology, 26(1-2), 37-42.

Cerebrospinal-fluid neuropeptides : A biochemical subgrouping approach. / Banki, C. M.; Karmacsi, L.; Bissette, G.; Nemeroff, Charles.

In: Neuropsychobiology, Vol. 26, No. 1-2, 01.01.1992, p. 37-42.

Research output: Contribution to journalArticle

Banki, CM, Karmacsi, L, Bissette, G & Nemeroff, C 1992, 'Cerebrospinal-fluid neuropeptides: A biochemical subgrouping approach', Neuropsychobiology, vol. 26, no. 1-2, pp. 37-42.
Banki, C. M. ; Karmacsi, L. ; Bissette, G. ; Nemeroff, Charles. / Cerebrospinal-fluid neuropeptides : A biochemical subgrouping approach. In: Neuropsychobiology. 1992 ; Vol. 26, No. 1-2. pp. 37-42.
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