Cerebrospinal fluid dopamine in HIV-1 infection

Joseph R. Berger, Mahendra Kumar, Adarsh Kumar, Jesus B. Fernandez, Bonnie Levin

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: Increasing evidence suggests significant involvement of the basal ganglia in patients with HIV-1 infection. Objective: To study the effect of HIV-1 infection on cerebrospinal fluid (CSF) dopamine levels. Design: CSF dopamine levels were measured by high-performance liquid chromatography. Setting: A university-based outpatient clinic in south Florida involved in clinical AIDS research. Subjects: Twenty-two subjects were enrolled in a prospective, longitudinal study of the neurological complications of AIDS. Five subjects were HIV-seronegative, but at risk for HIV-1 infection, 11 were HIV-1-seropositive without neurological disease and six had HIV-1-related neurological disease. Results: The CSF dopamine mean values were significantly lower in the HIV-1-seropositive group with (P < 0.0001) or without (P < 0.0001) neurological disease than in the HIV-seronegative group. There was a very strong correlation between CD4 lymphocyte counts and CSF dopamine levels (P = 0.004) in the neurologically symptomatic group (P = 0.0008), but not in the other two groups. Conclusion: HIV-1 infection appears to have an effect on the central nervous system dopaminergic systems, as reflected in levels of CSF dopamine.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalAIDS
Volume8
Issue number1
StatePublished - Jan 1 1994

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HIV Infections
Cerebrospinal Fluid
HIV-1
Dopamine
Acquired Immunodeficiency Syndrome
HIV
CD4 Lymphocyte Count
Ambulatory Care Facilities
Basal Ganglia
Longitudinal Studies
Central Nervous System
High Pressure Liquid Chromatography
Prospective Studies
Research

Keywords

  • AIDS
  • Brain
  • Cerebrospinal fluid
  • Dopamine
  • HIV-1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Berger, J. R., Kumar, M., Kumar, A., Fernandez, J. B., & Levin, B. (1994). Cerebrospinal fluid dopamine in HIV-1 infection. AIDS, 8(1), 67-71.

Cerebrospinal fluid dopamine in HIV-1 infection. / Berger, Joseph R.; Kumar, Mahendra; Kumar, Adarsh; Fernandez, Jesus B.; Levin, Bonnie.

In: AIDS, Vol. 8, No. 1, 01.01.1994, p. 67-71.

Research output: Contribution to journalArticle

Berger, JR, Kumar, M, Kumar, A, Fernandez, JB & Levin, B 1994, 'Cerebrospinal fluid dopamine in HIV-1 infection', AIDS, vol. 8, no. 1, pp. 67-71.
Berger JR, Kumar M, Kumar A, Fernandez JB, Levin B. Cerebrospinal fluid dopamine in HIV-1 infection. AIDS. 1994 Jan 1;8(1):67-71.
Berger, Joseph R. ; Kumar, Mahendra ; Kumar, Adarsh ; Fernandez, Jesus B. ; Levin, Bonnie. / Cerebrospinal fluid dopamine in HIV-1 infection. In: AIDS. 1994 ; Vol. 8, No. 1. pp. 67-71.
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