Abstract
Background: Increasing evidence suggests significant involvement of the basal ganglia in patients with HIV-1 infection. Objective: To study the effect of HIV-1 infection on cerebrospinal fluid (CSF) dopamine levels. Design: CSF dopamine levels were measured by high-performance liquid chromatography. Setting: A university-based outpatient clinic in south Florida involved in clinical AIDS research. Subjects: Twenty-two subjects were enrolled in a prospective, longitudinal study of the neurological complications of AIDS. Five subjects were HIV-seronegative, but at risk for HIV-1 infection, 11 were HIV-1-seropositive without neurological disease and six had HIV-1-related neurological disease. Results: The CSF dopamine mean values were significantly lower in the HIV-1-seropositive group with (P < 0.0001) or without (P < 0.0001) neurological disease than in the HIV-seronegative group. There was a very strong correlation between CD4 lymphocyte counts and CSF dopamine levels (P = 0.004) in the neurologically symptomatic group (P = 0.0008), but not in the other two groups. Conclusion: HIV-1 infection appears to have an effect on the central nervous system dopaminergic systems, as reflected in levels of CSF dopamine.
| Original language | English |
|---|---|
| Pages (from-to) | 67-71 |
| Number of pages | 5 |
| Journal | AIDS |
| Volume | 8 |
| Issue number | 1 |
| State | Published - Jan 1 1994 |
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Keywords
- AIDS
- Brain
- Cerebrospinal fluid
- Dopamine
- HIV-1
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Cerebrospinal fluid dopamine in HIV-1 infection. / Berger, Joseph R.; Kumar, Mahendra; Kumar, Adarsh; Fernandez, Jesus B.; Levin, Bonnie.
In: AIDS, Vol. 8, No. 1, 01.01.1994, p. 67-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerebrospinal fluid dopamine in HIV-1 infection
AU - Berger, Joseph R.
AU - Kumar, Mahendra
AU - Kumar, Adarsh
AU - Fernandez, Jesus B.
AU - Levin, Bonnie
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Background: Increasing evidence suggests significant involvement of the basal ganglia in patients with HIV-1 infection. Objective: To study the effect of HIV-1 infection on cerebrospinal fluid (CSF) dopamine levels. Design: CSF dopamine levels were measured by high-performance liquid chromatography. Setting: A university-based outpatient clinic in south Florida involved in clinical AIDS research. Subjects: Twenty-two subjects were enrolled in a prospective, longitudinal study of the neurological complications of AIDS. Five subjects were HIV-seronegative, but at risk for HIV-1 infection, 11 were HIV-1-seropositive without neurological disease and six had HIV-1-related neurological disease. Results: The CSF dopamine mean values were significantly lower in the HIV-1-seropositive group with (P < 0.0001) or without (P < 0.0001) neurological disease than in the HIV-seronegative group. There was a very strong correlation between CD4 lymphocyte counts and CSF dopamine levels (P = 0.004) in the neurologically symptomatic group (P = 0.0008), but not in the other two groups. Conclusion: HIV-1 infection appears to have an effect on the central nervous system dopaminergic systems, as reflected in levels of CSF dopamine.
AB - Background: Increasing evidence suggests significant involvement of the basal ganglia in patients with HIV-1 infection. Objective: To study the effect of HIV-1 infection on cerebrospinal fluid (CSF) dopamine levels. Design: CSF dopamine levels were measured by high-performance liquid chromatography. Setting: A university-based outpatient clinic in south Florida involved in clinical AIDS research. Subjects: Twenty-two subjects were enrolled in a prospective, longitudinal study of the neurological complications of AIDS. Five subjects were HIV-seronegative, but at risk for HIV-1 infection, 11 were HIV-1-seropositive without neurological disease and six had HIV-1-related neurological disease. Results: The CSF dopamine mean values were significantly lower in the HIV-1-seropositive group with (P < 0.0001) or without (P < 0.0001) neurological disease than in the HIV-seronegative group. There was a very strong correlation between CD4 lymphocyte counts and CSF dopamine levels (P = 0.004) in the neurologically symptomatic group (P = 0.0008), but not in the other two groups. Conclusion: HIV-1 infection appears to have an effect on the central nervous system dopaminergic systems, as reflected in levels of CSF dopamine.
KW - AIDS
KW - Brain
KW - Cerebrospinal fluid
KW - Dopamine
KW - HIV-1
UR - http://www.scopus.com/inward/record.url?scp=0028328411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028328411&partnerID=8YFLogxK
M3 - Article
C2 - 8011238
AN - SCOPUS:0028328411
VL - 8
SP - 67
EP - 71
JO - AIDS
JF - AIDS
SN - 0269-9370
IS - 1
ER -