Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects

Mark D. Fossey, R. Bruce Lydiard, James C. Ballenger, Michele T. Laraia, Garth Bissette, Charles B. Nemeroff

Research output: Contribution to journalArticle

61 Scopus citations


Cerebrospinal fluid (CSF) concentrations of corticotropin-releasing factor (CRF) were measured in a group of patients with anxiety disorders and normal comparison subjects (NC) to explore the hypothesis that abnormalities in CRF neuronal regulation occur in patients with anxiety disorders. Analysis of variance (ANOVA) revealed no differences in CSF CRF concentrations between the four diagnostic categories: panic disorder (PD), generalized anxiety disorder (GAD) obsessive-compulsive disorder (OCD), and NCs, Male OCD patients had higher CSF CRF concentrations than men with PD and GAD and male NCs. CSF CRF concentration was positively correlated with age in women but not in men. These findings suggest that central neuronal CRF regulation may be affected by both age and gender.

Original languageEnglish (US)
Pages (from-to)703-707
Number of pages5
JournalBiological Psychiatry
Issue number8
StatePublished - Apr 15 1996
Externally publishedYes



  • Anxiety
  • Cerebrospinal fluid
  • Corticotropin-releasing factor
  • Generalized anxiety disorder panic
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Biological Psychiatry

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