Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects

Mark D. Fossey, R. Bruce Lydiard, James C. Ballenger, Michele T. Laraia, Garth Bissette, Charles Nemeroff

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Cerebrospinal fluid (CSF) concentrations of corticotropin-releasing factor (CRF) were measured in a group of patients with anxiety disorders and normal comparison subjects (NC) to explore the hypothesis that abnormalities in CRF neuronal regulation occur in patients with anxiety disorders. Analysis of variance (ANOVA) revealed no differences in CSF CRF concentrations between the four diagnostic categories: panic disorder (PD), generalized anxiety disorder (GAD) obsessive-compulsive disorder (OCD), and NCs, Male OCD patients had higher CSF CRF concentrations than men with PD and GAD and male NCs. CSF CRF concentration was positively correlated with age in women but not in men. These findings suggest that central neuronal CRF regulation may be affected by both age and gender.

Original languageEnglish
Pages (from-to)703-707
Number of pages5
JournalBiological Psychiatry
Volume39
Issue number8
DOIs
StatePublished - Apr 15 1996
Externally publishedYes

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Corticotropin-Releasing Hormone
Anxiety Disorders
Cerebrospinal Fluid
Panic Disorder
Obsessive-Compulsive Disorder
Analysis of Variance

Keywords

  • Anxiety
  • Cerebrospinal fluid
  • Corticotropin-releasing factor
  • Generalized anxiety disorder panic
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects. / Fossey, Mark D.; Lydiard, R. Bruce; Ballenger, James C.; Laraia, Michele T.; Bissette, Garth; Nemeroff, Charles.

In: Biological Psychiatry, Vol. 39, No. 8, 15.04.1996, p. 703-707.

Research output: Contribution to journalArticle

Fossey, Mark D. ; Lydiard, R. Bruce ; Ballenger, James C. ; Laraia, Michele T. ; Bissette, Garth ; Nemeroff, Charles. / Cerebrospinal fluid corticotropin-releasing factor concentrations in patients with anxiety disorders and normal comparison subjects. In: Biological Psychiatry. 1996 ; Vol. 39, No. 8. pp. 703-707.
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