Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions

Jeremy D. Coplan, Ronald C. Trost, Michael J. Owens, Thomas B. Cooper, Jack M. Gorman, Charles Nemeroff, Leonard A. Rosenblum

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Background: In an earlier study, infant primates were nursed by mothers randomly assigned to variable foraging demand (VFD) or nonvariable foraging conditions (non-VFD). A group of grown VFD-reared subjects demonstrated elevations of cisternal cerebrospinal fluid (CSF) corticotropin-releasing factor concentrations and decreased CSF cortisol levels vs non-VFD counterparts. To further characterize neurobiological sequelae of disturbed early rearing, CSF concentrations of serotonin, dopamine, and norepinephrine metabolites (5-hydroxyindoleacetic acid, homovanillic acid, and 3-methoxy-4- hydroxyphenethyleneglycol [MHPG], respectively) and of somatostatin were determined. Methods: Second CSF taps were obtained from the previously studied cohort of 30 subjects and from 28 age-matched ad libitum-reared control subjects. Relevant assays were performed. Results: All neurochemicals assayed except MHPG were elevated in the VFD-reared compared with non-VFD subjects. In the VFD group, statistically significant positive correlations between corticotropin-releasing factor and each neurochemical was found, except for MHPG. In the non-VFD subjects, no significant correlations with corticotropin-releasing factor were observed. No effect of age was evident. Conclusions: Reducing the predictability of maternal foraging demand during early rearing was associated with elevations of cisternal somatostatin and of serotonin and dopamine metabolite concentrations in grown offspring. The corticotropin-releasing factor elevations reported previously were positively correlated with all the elevated CSF parameters of the current study. The findings support the notion that adverse early rearing experiences in primates have longstanding and complex effects on a range of neurochemicals relevant to emotional regulation. Replication in prospective age-controlled studies is warranted.

Original languageEnglish
Pages (from-to)473-477
Number of pages5
JournalArchives of General Psychiatry
Volume55
Issue number5
DOIs
StatePublished - Jun 4 1998
Externally publishedYes

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Biogenic Amines
Somatostatin
Primates
Corticotropin-Releasing Hormone
Cerebrospinal Fluid
Mothers
Dopamine
Serotonin
Homovanillic Acid
Hydroxyindoleacetic Acid
Hydrocortisone
Norepinephrine

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions. / Coplan, Jeremy D.; Trost, Ronald C.; Owens, Michael J.; Cooper, Thomas B.; Gorman, Jack M.; Nemeroff, Charles; Rosenblum, Leonard A.

In: Archives of General Psychiatry, Vol. 55, No. 5, 04.06.1998, p. 473-477.

Research output: Contribution to journalArticle

Coplan, Jeremy D. ; Trost, Ronald C. ; Owens, Michael J. ; Cooper, Thomas B. ; Gorman, Jack M. ; Nemeroff, Charles ; Rosenblum, Leonard A. / Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions. In: Archives of General Psychiatry. 1998 ; Vol. 55, No. 5. pp. 473-477.
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AU - Gorman, Jack M.

AU - Nemeroff, Charles

AU - Rosenblum, Leonard A.

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AB - Background: In an earlier study, infant primates were nursed by mothers randomly assigned to variable foraging demand (VFD) or nonvariable foraging conditions (non-VFD). A group of grown VFD-reared subjects demonstrated elevations of cisternal cerebrospinal fluid (CSF) corticotropin-releasing factor concentrations and decreased CSF cortisol levels vs non-VFD counterparts. To further characterize neurobiological sequelae of disturbed early rearing, CSF concentrations of serotonin, dopamine, and norepinephrine metabolites (5-hydroxyindoleacetic acid, homovanillic acid, and 3-methoxy-4- hydroxyphenethyleneglycol [MHPG], respectively) and of somatostatin were determined. Methods: Second CSF taps were obtained from the previously studied cohort of 30 subjects and from 28 age-matched ad libitum-reared control subjects. Relevant assays were performed. Results: All neurochemicals assayed except MHPG were elevated in the VFD-reared compared with non-VFD subjects. In the VFD group, statistically significant positive correlations between corticotropin-releasing factor and each neurochemical was found, except for MHPG. In the non-VFD subjects, no significant correlations with corticotropin-releasing factor were observed. No effect of age was evident. Conclusions: Reducing the predictability of maternal foraging demand during early rearing was associated with elevations of cisternal somatostatin and of serotonin and dopamine metabolite concentrations in grown offspring. The corticotropin-releasing factor elevations reported previously were positively correlated with all the elevated CSF parameters of the current study. The findings support the notion that adverse early rearing experiences in primates have longstanding and complex effects on a range of neurochemicals relevant to emotional regulation. Replication in prospective age-controlled studies is warranted.

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