Cerebrospinal fluid concentrations of neurotensin and corticotropin-releasing factor in pediatric patients

J. Hedner; T. Hedner; K. H. Lundell; G. Bissette; L. O'Connor; C. B. Nemeroff

doi:10.1159/000242927

Cerebrospinal fluid concentrations of neurotensin and corticotropin-releasing factor in pediatric patients

J. Hedner, T. Hedner, K. H. Lundell, G. Bissette, L. O'Connor, C. B. Nemeroff

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cerebrospinal fluid (CSF) concentrations of neurotensin (NT) and corticotropin-releasing hormone (CRF)-like immunoreactive materials (LIM) were measured in 22 infant and children 6 days to 15 years of age. For both neuropeptides there was a marked age-related exponential decline in CSF concentrations. The most prominent decrease in CSF neuropeptide concentrations was seen during the first 24 months of postnatal life. From 1 year and on there was no or only minimal age-associated alteration in CSF neuropeptide concentrations. In this group of children (1-15 years) mean CSF concentrations of NT-LIM and CRF-LIM were 36.8 ± 4.32 and 65.9 ± 4.63 pg/ml, respectively. As CSF neuropeptide concentrations are apparently independent of circulating serum concentrations, they may reflect functional activity of neuropeptide-containing neurons and therefore may be of value in the assessment of the role of peptides in the human central nervous system function and behavior.

Original language	English (US)
Pages (from-to)	260-267
Number of pages	8
Journal	Biology of the Neonate
Volume	55
Issue number	4-5
DOIs	https://doi.org/10.1159/000242927
State	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

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title = "Cerebrospinal fluid concentrations of neurotensin and corticotropin-releasing factor in pediatric patients",

abstract = "Cerebrospinal fluid (CSF) concentrations of neurotensin (NT) and corticotropin-releasing hormone (CRF)-like immunoreactive materials (LIM) were measured in 22 infant and children 6 days to 15 years of age. For both neuropeptides there was a marked age-related exponential decline in CSF concentrations. The most prominent decrease in CSF neuropeptide concentrations was seen during the first 24 months of postnatal life. From 1 year and on there was no or only minimal age-associated alteration in CSF neuropeptide concentrations. In this group of children (1-15 years) mean CSF concentrations of NT-LIM and CRF-LIM were 36.8 ± 4.32 and 65.9 ± 4.63 pg/ml, respectively. As CSF neuropeptide concentrations are apparently independent of circulating serum concentrations, they may reflect functional activity of neuropeptide-containing neurons and therefore may be of value in the assessment of the role of peptides in the human central nervous system function and behavior.",

author = "J. Hedner and T. Hedner and Lundell, {K. H.} and G. Bissette and L. O'Connor and Nemeroff, {C. B.}",

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T1 - Cerebrospinal fluid concentrations of neurotensin and corticotropin-releasing factor in pediatric patients

AU - Hedner, J.

AU - Hedner, T.

AU - Lundell, K. H.

AU - Bissette, G.

AU - O'Connor, L.

AU - Nemeroff, C. B.

PY - 1989

Y1 - 1989

N2 - Cerebrospinal fluid (CSF) concentrations of neurotensin (NT) and corticotropin-releasing hormone (CRF)-like immunoreactive materials (LIM) were measured in 22 infant and children 6 days to 15 years of age. For both neuropeptides there was a marked age-related exponential decline in CSF concentrations. The most prominent decrease in CSF neuropeptide concentrations was seen during the first 24 months of postnatal life. From 1 year and on there was no or only minimal age-associated alteration in CSF neuropeptide concentrations. In this group of children (1-15 years) mean CSF concentrations of NT-LIM and CRF-LIM were 36.8 ± 4.32 and 65.9 ± 4.63 pg/ml, respectively. As CSF neuropeptide concentrations are apparently independent of circulating serum concentrations, they may reflect functional activity of neuropeptide-containing neurons and therefore may be of value in the assessment of the role of peptides in the human central nervous system function and behavior.

AB - Cerebrospinal fluid (CSF) concentrations of neurotensin (NT) and corticotropin-releasing hormone (CRF)-like immunoreactive materials (LIM) were measured in 22 infant and children 6 days to 15 years of age. For both neuropeptides there was a marked age-related exponential decline in CSF concentrations. The most prominent decrease in CSF neuropeptide concentrations was seen during the first 24 months of postnatal life. From 1 year and on there was no or only minimal age-associated alteration in CSF neuropeptide concentrations. In this group of children (1-15 years) mean CSF concentrations of NT-LIM and CRF-LIM were 36.8 ± 4.32 and 65.9 ± 4.63 pg/ml, respectively. As CSF neuropeptide concentrations are apparently independent of circulating serum concentrations, they may reflect functional activity of neuropeptide-containing neurons and therefore may be of value in the assessment of the role of peptides in the human central nervous system function and behavior.

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