Cerebrospinal fluid concentrations of neurotensin and corticotropin-releasing factor in pediatric patients

J. Hedner, T. Hedner, K. H. Lundell, G. Bissette, L. O'Connor, C. B. Nemeroff

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Cerebrospinal fluid (CSF) concentrations of neurotensin (NT) and corticotropin-releasing hormone (CRF)-like immunoreactive materials (LIM) were measured in 22 infant and children 6 days to 15 years of age. For both neuropeptides there was a marked age-related exponential decline in CSF concentrations. The most prominent decrease in CSF neuropeptide concentrations was seen during the first 24 months of postnatal life. From 1 year and on there was no or only minimal age-associated alteration in CSF neuropeptide concentrations. In this group of children (1-15 years) mean CSF concentrations of NT-LIM and CRF-LIM were 36.8 ± 4.32 and 65.9 ± 4.63 pg/ml, respectively. As CSF neuropeptide concentrations are apparently independent of circulating serum concentrations, they may reflect functional activity of neuropeptide-containing neurons and therefore may be of value in the assessment of the role of peptides in the human central nervous system function and behavior.

Original languageEnglish (US)
Pages (from-to)260-267
Number of pages8
JournalBiology of the Neonate
Volume55
Issue number4-5
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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