Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment

I. Heuser, G. Bissette, M. Dettling, U. Schweiger, U. Gotthardt, J. Schmider, C. H. Lammers, Charles Nemeroff, F. Holsboer

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

The effect of amitriptyline upon hypothalamic-pituitary-adrenal [HPA]- system-regulating neuropeptides (corticotropin-releasing hormone [CRH], vasopressin, somatostatin) was studied in a group of depressed elderly patients and controls. A first lumbar puncture was performed in 37 depressed in-patients. This was followed by a 6-week medication phase with amitriptyline. Upon its completion a second cerebrospinal fluid (CSF) sample was obtained in 18 of these 37 patients. In 25 healthy controls a first lumbar puncture was done; eleven of these individuals agreed to take 75 mg/d amitriptyline for 6 weeks and to participate in the follow-up CSF study. Within the group of depressed patients amitriptyline led to a significant decrease of CSF CRH in treatment responders only (F(1,16) = 5.2; P < 0.02). Also, in normal controls CSF CRH concentration tended to decrease with amitriptyline treatment (t-test; P < 0.09). No effects of amitriptyline upon vasopressin or somatostatin were observed. In normal controls (r = 0.4; P < 0.02) and in patients (r = 0.4; P < 0.03) age correlated positively with baseline CSF somatostatin. A trend for CSF CRH to increase with aging was found only in controls (r = 0.3; P < 0.09); patients did not show a significant association here. Finally, CSF neuropeptide concentration at baseline did not differ between the group of depressed patients and healthy controls. Our study corroborates the evolving concept that antidepressants effect various components of the HPA system with the net result of a reduction in its activity. In addition, we found CSF CRH and CSF somatostatin concentrations to be better reflections of age than of depression and, finally, that during aging and during depression the HPA system changes in similar directions.

Original languageEnglish
Pages (from-to)71-79
Number of pages9
JournalDepression and Anxiety
Volume8
Issue number2
DOIs
StatePublished - Oct 16 1998
Externally publishedYes

Fingerprint

Amitriptyline
Corticotropin-Releasing Hormone
Somatostatin
Vasopressins
Cerebrospinal Fluid
Pituitary-Adrenal System
Spinal Puncture
Therapeutics
Neuropeptides
Antidepressive Agents

Keywords

  • Amitriptyline
  • Corticotropin-releasing hormone
  • Somatostatin
  • Vasopressin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls : Response to amitriptyline treatment. / Heuser, I.; Bissette, G.; Dettling, M.; Schweiger, U.; Gotthardt, U.; Schmider, J.; Lammers, C. H.; Nemeroff, Charles; Holsboer, F.

In: Depression and Anxiety, Vol. 8, No. 2, 16.10.1998, p. 71-79.

Research output: Contribution to journalArticle

Heuser, I. ; Bissette, G. ; Dettling, M. ; Schweiger, U. ; Gotthardt, U. ; Schmider, J. ; Lammers, C. H. ; Nemeroff, Charles ; Holsboer, F. / Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls : Response to amitriptyline treatment. In: Depression and Anxiety. 1998 ; Vol. 8, No. 2. pp. 71-79.
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