Cerebro-renal interaction and stroke

Birva Shah, Priya Jagtap, Deepaneeta Sarmah, Aishika Datta, Swapnil Raut, Ankan Sarkar, Mariya Bohra, Upasna Singh, Falguni Baidya, Kiran Kalia, Anupom Borah, Kunjan R. Dave, Dileep R Yavagal, Pallab Bhattacharya

Research output: Contribution to journalReview articlepeer-review

Abstract

Stroke is an event causing a disturbance in cerebral function leading to death and disability worldwide. Both acute kidney injury and chronic kidney disease (CKD) are associated with an increased risk of stroke and cerebrovascular events. The underlying mechanistic approach between impaired renal function and stroke is limitedly explored and has attracted researchers to learn more for developing therapeutic intervention. Common risk factors such as hypertension, hyperphosphatemia, atrial fibrillation, arteriosclerosis, hyperhomocysteinemia, blood-brain barrier disruption, inflammation, etc. are observed in the general population, but are high in renal failure patients. Also, risk factors like bone mineral metabolism, uremic toxins, and anemia, along with the process of dialysis in CKD patients, eventually increases the risk of stroke. Therefore, early detection of risks associated with stroke in CKD is imperative, which may decrease the mortality associated with it. This review highlights mechanisms by which kidney dysfunction can lead to cerebrovascular events and increase the risk of stroke in renal impairment.

Original languageEnglish (US)
JournalEuropean Journal of Neuroscience
DOIs
StateAccepted/In press - 2020

Keywords

  • cerebrorenal interactions
  • chronic kidney disease
  • endothelial dysfunction
  • stroke
  • uremic toxins

ASJC Scopus subject areas

  • Neuroscience(all)

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