Cerebral Vascular Toxicity of Antiretroviral Therapy

Luc Bertrand, Martina Velichkovska, Michal J Toborek

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

HIV infection is associated with comorbidities that are likely to be driven not only by HIV itself, but also by the toxicity of long-term use of antiretroviral therapy (ART). Indeed, increasing evidence demonstrates that the antiretroviral drugs used for HIV treatment have toxic effects resulting in various cellular and tissue pathologies. The blood-brain barrier (BBB) is a modulated anatomophysiological interface which separates and controls substance exchange between the blood and the brain parenchyma; therefore, it is particularly exposed to ART-induced toxicity. Balancing the health risks and gains of ART has to be considered in order to maximize the positive effects of therapy. The current review discusses the cerebrovascular toxicity of ART, with the focus on mitochondrial dysfunction. [Figure not available: see fulltext.].

Original languageEnglish (US)
JournalJournal of Neuroimmune Pharmacology
DOIs
StatePublished - Jan 1 2019
Externally publishedYes

Fingerprint

Blood Vessels
HIV
Therapeutics
Poisons
Blood-Brain Barrier
HIV Infections
Comorbidity
Pathology
Health
Brain
Pharmaceutical Preparations

Keywords

  • Antiretroviral therapy
  • Blood-brain barrier
  • Cerebrovascular toxicity
  • Mitochondria
  • Neurotoxicity

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Cerebral Vascular Toxicity of Antiretroviral Therapy. / Bertrand, Luc; Velichkovska, Martina; Toborek, Michal J.

In: Journal of Neuroimmune Pharmacology, 01.01.2019.

Research output: Contribution to journalReview article

@article{73f3c9ab622b4aafbb11816024cae333,
title = "Cerebral Vascular Toxicity of Antiretroviral Therapy",
abstract = "HIV infection is associated with comorbidities that are likely to be driven not only by HIV itself, but also by the toxicity of long-term use of antiretroviral therapy (ART). Indeed, increasing evidence demonstrates that the antiretroviral drugs used for HIV treatment have toxic effects resulting in various cellular and tissue pathologies. The blood-brain barrier (BBB) is a modulated anatomophysiological interface which separates and controls substance exchange between the blood and the brain parenchyma; therefore, it is particularly exposed to ART-induced toxicity. Balancing the health risks and gains of ART has to be considered in order to maximize the positive effects of therapy. The current review discusses the cerebrovascular toxicity of ART, with the focus on mitochondrial dysfunction. [Figure not available: see fulltext.].",
keywords = "Antiretroviral therapy, Blood-brain barrier, Cerebrovascular toxicity, Mitochondria, Neurotoxicity",
author = "Luc Bertrand and Martina Velichkovska and Toborek, {Michal J}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s11481-019-09858-x",
language = "English (US)",
journal = "Journal of NeuroImmune Pharmacology",
issn = "1557-1890",
publisher = "Springer New York",

}

TY - JOUR

T1 - Cerebral Vascular Toxicity of Antiretroviral Therapy

AU - Bertrand, Luc

AU - Velichkovska, Martina

AU - Toborek, Michal J

PY - 2019/1/1

Y1 - 2019/1/1

N2 - HIV infection is associated with comorbidities that are likely to be driven not only by HIV itself, but also by the toxicity of long-term use of antiretroviral therapy (ART). Indeed, increasing evidence demonstrates that the antiretroviral drugs used for HIV treatment have toxic effects resulting in various cellular and tissue pathologies. The blood-brain barrier (BBB) is a modulated anatomophysiological interface which separates and controls substance exchange between the blood and the brain parenchyma; therefore, it is particularly exposed to ART-induced toxicity. Balancing the health risks and gains of ART has to be considered in order to maximize the positive effects of therapy. The current review discusses the cerebrovascular toxicity of ART, with the focus on mitochondrial dysfunction. [Figure not available: see fulltext.].

AB - HIV infection is associated with comorbidities that are likely to be driven not only by HIV itself, but also by the toxicity of long-term use of antiretroviral therapy (ART). Indeed, increasing evidence demonstrates that the antiretroviral drugs used for HIV treatment have toxic effects resulting in various cellular and tissue pathologies. The blood-brain barrier (BBB) is a modulated anatomophysiological interface which separates and controls substance exchange between the blood and the brain parenchyma; therefore, it is particularly exposed to ART-induced toxicity. Balancing the health risks and gains of ART has to be considered in order to maximize the positive effects of therapy. The current review discusses the cerebrovascular toxicity of ART, with the focus on mitochondrial dysfunction. [Figure not available: see fulltext.].

KW - Antiretroviral therapy

KW - Blood-brain barrier

KW - Cerebrovascular toxicity

KW - Mitochondria

KW - Neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=85067807057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85067807057&partnerID=8YFLogxK

U2 - 10.1007/s11481-019-09858-x

DO - 10.1007/s11481-019-09858-x

M3 - Review article

AN - SCOPUS:85067807057

JO - Journal of NeuroImmune Pharmacology

JF - Journal of NeuroImmune Pharmacology

SN - 1557-1890

ER -