Cerebral ischemic damage in diabetes

An inflammatory perspective

Vibha Shukla, Akhalesh Kumar Shakya, Miguel Perez-Pinzon, Kunjan R Dave

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Stroke is one of the leading causes of death worldwide. A strong inflammatory response characterized by activation and release of cytokines, chemokines, adhesion molecules, and proteolytic enzymes contributes to brain damage following stroke. Stroke outcomes are worse among diabetics, resulting in increased mortality and disabilities. Diabetes involves chronic inflammation manifested by reactive oxygen species generation, expression of proinflammatory cytokines, and activation/expression of other inflammatory mediators. It appears that increased proinflammatory processes due to diabetes are further accelerated after cerebral ischemia, leading to increased ischemic damage. Hypoglycemia is an intrinsic side effect owing to glucose-lowering therapy in diabetics, and is known to induce proinflammatory changes as well as exacerbate cerebral damage in experimental stroke. Here, we present a review of available literature on the contribution of neuroinflammation to increased cerebral ischemic damage in diabetics. We also describe the role of hypoglycemia in neuroinflammation and cerebral ischemic damage in diabetics. Understanding the role of neuroinflammatory mechanisms in worsening stroke outcome in diabetics may help limit ischemic brain injury and improve clinical outcomes.

Original languageEnglish (US)
Article number21
JournalJournal of Neuroinflammation
Volume14
Issue number1
DOIs
StatePublished - Jan 23 2017

Fingerprint

Stroke
Hypoglycemia
Cytokines
Brain Ischemia
Chemokines
Brain Injuries
Cause of Death
Reactive Oxygen Species
Peptide Hydrolases
Inflammation
Glucose
Mortality
Brain
Therapeutics

Keywords

  • Cell death
  • Chemokines
  • Cytokines
  • Diabetic brain
  • Hyperglycemia
  • Hypoglycemia
  • Immune cells
  • Inflammation
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Cerebral ischemic damage in diabetes : An inflammatory perspective. / Shukla, Vibha; Shakya, Akhalesh Kumar; Perez-Pinzon, Miguel; Dave, Kunjan R.

In: Journal of Neuroinflammation, Vol. 14, No. 1, 21, 23.01.2017.

Research output: Contribution to journalReview article

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