Cerebral ischemia in diabetics and oxidative stress

Sunjoo Cho, Perry Fuchs, Deepaneeta Sarmah, Harpreet Kaur, Pallab Bhattacharya, Kunjan R. Dave

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cerebral ischemia is one of the major complications of diabetes. Eighty-four percent of diabetics die from either heart disease or stroke (both cause cerebral ischemia). Diabetes-induced oxidative stress is one of the factors responsible for the secondary complications of diabetes, even after diabetes treatment. Oxidative stress also causes an increase in cerebral ischemic damage, resulting in the activation of necrotic and apoptotic pathways. In this chapter, we provide a literature review on how cerebral ischemia-induced oxidative stress is exacerbated in diabetics. We also provide correlates of how this increased oxidative stress may be responsible for increased cerebral ischemia damage in diabetics.

Original languageEnglish (US)
Title of host publicationDiabetes
Subtitle of host publicationOxidative Stress and Dietary Antioxidants
PublisherElsevier
Pages59-68
Number of pages10
ISBN (Electronic)9780128157763
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Cerebral ischemia
  • Diabetes
  • Free radicals
  • Ischemic damage
  • Reactive oxygen species
  • Stroke

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)

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