Cerebral ischemia and neuroregeneration

Reggie H.C. Lee; Michelle H.H. Lee; Celeste Y.C. Wu; Alexandre Couto E Silva; Harlee E. Possoit; Tsung Han Hsieh; Alireza Minagar; Hung Wen Lin

doi:10.4103/1673-5374.228711

Cerebral ischemia and neuroregeneration

Reggie H.C. Lee, Michelle H.H. Lee, Celeste Y.C. Wu, Alexandre Couto E Silva, Harlee E. Possoit, Tsung Han Hsieh, Alireza Minagar, Hung Wen Lin

Neurology

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.

Original language	English (US)
Pages (from-to)	373-385
Number of pages	13
Journal	Neural Regeneration Research
Volume	13
Issue number	3
DOIs	https://doi.org/10.4103/1673-5374.228711
State	Published - Mar 2018

Keywords

Cerebral ischemia
Fatty acids
Melatonin
Neuromodulation therapy
Pifithrin-α
Protein kinase C
Resveratrol
Stem cell
Sympathetic nervous system
Traditional Chinese therapies

ASJC Scopus subject areas

Developmental Neuroscience

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title = "Cerebral ischemia and neuroregeneration",

abstract = "Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.",

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author = "Lee, {Reggie H.C.} and Lee, {Michelle H.H.} and Wu, {Celeste Y.C.} and {Couto E Silva}, Alexandre and Possoit, {Harlee E.} and Hsieh, {Tsung Han} and Alireza Minagar and Lin, {Hung Wen}",

year = "2018",

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AU - Lee, Reggie H.C.

AU - Lee, Michelle H.H.

AU - Wu, Celeste Y.C.

AU - Couto E Silva, Alexandre

AU - Possoit, Harlee E.

AU - Hsieh, Tsung Han

AU - Minagar, Alireza

AU - Lin, Hung Wen

PY - 2018/3

Y1 - 2018/3

N2 - Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.

AB - Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.

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KW - Neuromodulation therapy

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KW - Sympathetic nervous system

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