Cerebral ischemia and neuroregeneration

Reggie H.C. Lee, Michelle H.H. Lee, Celeste Y.C. Wu, Alexandre Couto E Silva, Harlee E. Possoit, Tsung Han Hsieh, Alireza Minagar, Hung Wen Lin

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations


Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)373-385
Number of pages13
JournalNeural Regeneration Research
Issue number3
StatePublished - Mar 2018


  • Cerebral ischemia
  • Fatty acids
  • Melatonin
  • Neuromodulation therapy
  • Pifithrin-α
  • Protein kinase C
  • Resveratrol
  • Stem cell
  • Sympathetic nervous system
  • Traditional Chinese therapies

ASJC Scopus subject areas

  • Developmental Neuroscience


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