Abstract
Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 373-385 |
| Number of pages | 13 |
| Journal | Neural Regeneration Research |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2018 |
| Externally published | Yes |
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Keywords
- Cerebral ischemia
- Fatty acids
- Melatonin
- Neuromodulation therapy
- Pifithrin-α
- Protein kinase C
- Resveratrol
- Stem cell
- Sympathetic nervous system
- Traditional Chinese therapies
ASJC Scopus subject areas
- Developmental Neuroscience
Cite this
Cerebral ischemia and neuroregeneration. / Lee, Reggie H.C.; Lee, Michelle H.H.; Wu, Celeste Y.C.; Couto E Silva, Alexandre; Possoit, Harlee E.; Hsieh, Tsung Han; Minagar, Alireza; Wen Lin, Hung.
In: Neural Regeneration Research, Vol. 13, No. 3, 01.03.2018, p. 373-385.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cerebral ischemia and neuroregeneration
AU - Lee, Reggie H.C.
AU - Lee, Michelle H.H.
AU - Wu, Celeste Y.C.
AU - Couto E Silva, Alexandre
AU - Possoit, Harlee E.
AU - Hsieh, Tsung Han
AU - Minagar, Alireza
AU - Wen Lin, Hung
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.
AB - Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke (a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics (i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies (i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia.
KW - Cerebral ischemia
KW - Fatty acids
KW - Melatonin
KW - Neuromodulation therapy
KW - Pifithrin-α
KW - Protein kinase C
KW - Resveratrol
KW - Stem cell
KW - Sympathetic nervous system
KW - Traditional Chinese therapies
UR - http://www.scopus.com/inward/record.url?scp=85049833023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049833023&partnerID=8YFLogxK
U2 - 10.4103/1673-5374.228711
DO - 10.4103/1673-5374.228711
M3 - Review article
AN - SCOPUS:85049833023
VL - 13
SP - 373
EP - 385
JO - Neural Regeneration Research
JF - Neural Regeneration Research
SN - 1673-5374
IS - 3
ER -