Cerebral hemodynamics in the elderly a transcranial doppler study in the Einstein aging study cohort

Dixon Yang, Digna Cabral, Emmanuel N. Gaspard, Richard B. Lipton, Tatjana Rundek, Carol A. Derby

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives-We sought to describe the relationship between age, sex, and race/ethnicity with transcranial Doppler hemodynamic characteristics from major intracerebral arterial segments in a large elderly population with varying demographics. Methods-We analyzed 369 stroke-free participants aged 70 years and older from the Einstein Aging Study. Single-gate, nonimaging transcranial Doppler sonography, a noninvasive sonographic technique that assesses real-time cerebrovascular hemodynamics, was used to interrogate 9 cerebral arterial segments. Individual Doppler spectra and cerebral blood flow velocities were acquired, and the pulsatility index and resistive index were calculated by the device's automated waveform-tracking function. Multiple linear regression models were used to examine the independent associations of age, sex, and race/ethnicity with transcranial Doppler measures, adjusting for hypertension, history of myocardial infarction or revascularization, and history of diabetes. Results-Among enrolled participants, 303 individuals had at least 1 vessel insonated (mean age [SD], 80 [6] years; 63% women; 58% white; and 32% black). With age, transcranial Doppler measures of mean blood flow velocity were significantly decreased in the basilar artery (P = .001) and posterior cerebral artery (right, P = .003; left, P = .02). Pulsatility indices increased in the left middle cerebral artery (P = .01) and left anterior cerebral artery (P = .03), and the resistive index was increased in the left middle cerebral artery (P= .007) with age. Women had higher pulsatility and resistive indices compared to men in several vessels. Conclusions-We report a decreased mean blood flow velocity and weakly increased arterial pulsatility and resistance with aging in a large elderly stroke-free population. These referential trends in cerebrovascular hemodynamics may carry important implications in vascular diseases associated with advanced age, increased risk of cerebrovascular disease, cognitive decline, and dementia.

Original languageEnglish (US)
Pages (from-to)1907-1914
Number of pages8
JournalJournal of Ultrasound in Medicine
Volume35
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Blood Flow Velocity
Cohort Studies
Hemodynamics
Middle Cerebral Artery
Linear Models
Cerebrovascular Circulation
Stroke
Posterior Cerebral Artery
Doppler Transcranial Ultrasonography
Anterior Cerebral Artery
Cerebrovascular Disorders
Myocardial Revascularization
Basilar Artery
Vascular Diseases
Population
Dementia
Myocardial Infarction
Demography
Hypertension
Equipment and Supplies

Keywords

  • Aging
  • Blood flow velocities
  • Cerebral hemodynamics
  • Head and neck ultrasound
  • Pulsatiliy index
  • Resistive index
  • Transcranial Doppler sonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Cerebral hemodynamics in the elderly a transcranial doppler study in the Einstein aging study cohort. / Yang, Dixon; Cabral, Digna; Gaspard, Emmanuel N.; Lipton, Richard B.; Rundek, Tatjana; Derby, Carol A.

In: Journal of Ultrasound in Medicine, Vol. 35, No. 9, 01.09.2016, p. 1907-1914.

Research output: Contribution to journalArticle

Yang, Dixon ; Cabral, Digna ; Gaspard, Emmanuel N. ; Lipton, Richard B. ; Rundek, Tatjana ; Derby, Carol A. / Cerebral hemodynamics in the elderly a transcranial doppler study in the Einstein aging study cohort. In: Journal of Ultrasound in Medicine. 2016 ; Vol. 35, No. 9. pp. 1907-1914.
@article{ec245431dec54c658bdb835e57e44ed4,
title = "Cerebral hemodynamics in the elderly a transcranial doppler study in the Einstein aging study cohort",
abstract = "Objectives-We sought to describe the relationship between age, sex, and race/ethnicity with transcranial Doppler hemodynamic characteristics from major intracerebral arterial segments in a large elderly population with varying demographics. Methods-We analyzed 369 stroke-free participants aged 70 years and older from the Einstein Aging Study. Single-gate, nonimaging transcranial Doppler sonography, a noninvasive sonographic technique that assesses real-time cerebrovascular hemodynamics, was used to interrogate 9 cerebral arterial segments. Individual Doppler spectra and cerebral blood flow velocities were acquired, and the pulsatility index and resistive index were calculated by the device's automated waveform-tracking function. Multiple linear regression models were used to examine the independent associations of age, sex, and race/ethnicity with transcranial Doppler measures, adjusting for hypertension, history of myocardial infarction or revascularization, and history of diabetes. Results-Among enrolled participants, 303 individuals had at least 1 vessel insonated (mean age [SD], 80 [6] years; 63{\%} women; 58{\%} white; and 32{\%} black). With age, transcranial Doppler measures of mean blood flow velocity were significantly decreased in the basilar artery (P = .001) and posterior cerebral artery (right, P = .003; left, P = .02). Pulsatility indices increased in the left middle cerebral artery (P = .01) and left anterior cerebral artery (P = .03), and the resistive index was increased in the left middle cerebral artery (P= .007) with age. Women had higher pulsatility and resistive indices compared to men in several vessels. Conclusions-We report a decreased mean blood flow velocity and weakly increased arterial pulsatility and resistance with aging in a large elderly stroke-free population. These referential trends in cerebrovascular hemodynamics may carry important implications in vascular diseases associated with advanced age, increased risk of cerebrovascular disease, cognitive decline, and dementia.",
keywords = "Aging, Blood flow velocities, Cerebral hemodynamics, Head and neck ultrasound, Pulsatiliy index, Resistive index, Transcranial Doppler sonography",
author = "Dixon Yang and Digna Cabral and Gaspard, {Emmanuel N.} and Lipton, {Richard B.} and Tatjana Rundek and Derby, {Carol A.}",
year = "2016",
month = "9",
day = "1",
doi = "10.7863/ultra.15.10040",
language = "English (US)",
volume = "35",
pages = "1907--1914",
journal = "Journal of Ultrasound in Medicine",
issn = "0278-4297",
publisher = "American Institute of Ultrasound in Medicine",
number = "9",

}

TY - JOUR

T1 - Cerebral hemodynamics in the elderly a transcranial doppler study in the Einstein aging study cohort

AU - Yang, Dixon

AU - Cabral, Digna

AU - Gaspard, Emmanuel N.

AU - Lipton, Richard B.

AU - Rundek, Tatjana

AU - Derby, Carol A.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Objectives-We sought to describe the relationship between age, sex, and race/ethnicity with transcranial Doppler hemodynamic characteristics from major intracerebral arterial segments in a large elderly population with varying demographics. Methods-We analyzed 369 stroke-free participants aged 70 years and older from the Einstein Aging Study. Single-gate, nonimaging transcranial Doppler sonography, a noninvasive sonographic technique that assesses real-time cerebrovascular hemodynamics, was used to interrogate 9 cerebral arterial segments. Individual Doppler spectra and cerebral blood flow velocities were acquired, and the pulsatility index and resistive index were calculated by the device's automated waveform-tracking function. Multiple linear regression models were used to examine the independent associations of age, sex, and race/ethnicity with transcranial Doppler measures, adjusting for hypertension, history of myocardial infarction or revascularization, and history of diabetes. Results-Among enrolled participants, 303 individuals had at least 1 vessel insonated (mean age [SD], 80 [6] years; 63% women; 58% white; and 32% black). With age, transcranial Doppler measures of mean blood flow velocity were significantly decreased in the basilar artery (P = .001) and posterior cerebral artery (right, P = .003; left, P = .02). Pulsatility indices increased in the left middle cerebral artery (P = .01) and left anterior cerebral artery (P = .03), and the resistive index was increased in the left middle cerebral artery (P= .007) with age. Women had higher pulsatility and resistive indices compared to men in several vessels. Conclusions-We report a decreased mean blood flow velocity and weakly increased arterial pulsatility and resistance with aging in a large elderly stroke-free population. These referential trends in cerebrovascular hemodynamics may carry important implications in vascular diseases associated with advanced age, increased risk of cerebrovascular disease, cognitive decline, and dementia.

AB - Objectives-We sought to describe the relationship between age, sex, and race/ethnicity with transcranial Doppler hemodynamic characteristics from major intracerebral arterial segments in a large elderly population with varying demographics. Methods-We analyzed 369 stroke-free participants aged 70 years and older from the Einstein Aging Study. Single-gate, nonimaging transcranial Doppler sonography, a noninvasive sonographic technique that assesses real-time cerebrovascular hemodynamics, was used to interrogate 9 cerebral arterial segments. Individual Doppler spectra and cerebral blood flow velocities were acquired, and the pulsatility index and resistive index were calculated by the device's automated waveform-tracking function. Multiple linear regression models were used to examine the independent associations of age, sex, and race/ethnicity with transcranial Doppler measures, adjusting for hypertension, history of myocardial infarction or revascularization, and history of diabetes. Results-Among enrolled participants, 303 individuals had at least 1 vessel insonated (mean age [SD], 80 [6] years; 63% women; 58% white; and 32% black). With age, transcranial Doppler measures of mean blood flow velocity were significantly decreased in the basilar artery (P = .001) and posterior cerebral artery (right, P = .003; left, P = .02). Pulsatility indices increased in the left middle cerebral artery (P = .01) and left anterior cerebral artery (P = .03), and the resistive index was increased in the left middle cerebral artery (P= .007) with age. Women had higher pulsatility and resistive indices compared to men in several vessels. Conclusions-We report a decreased mean blood flow velocity and weakly increased arterial pulsatility and resistance with aging in a large elderly stroke-free population. These referential trends in cerebrovascular hemodynamics may carry important implications in vascular diseases associated with advanced age, increased risk of cerebrovascular disease, cognitive decline, and dementia.

KW - Aging

KW - Blood flow velocities

KW - Cerebral hemodynamics

KW - Head and neck ultrasound

KW - Pulsatiliy index

KW - Resistive index

KW - Transcranial Doppler sonography

UR - http://www.scopus.com/inward/record.url?scp=84984917646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984917646&partnerID=8YFLogxK

U2 - 10.7863/ultra.15.10040

DO - 10.7863/ultra.15.10040

M3 - Article

C2 - 27417737

AN - SCOPUS:84984917646

VL - 35

SP - 1907

EP - 1914

JO - Journal of Ultrasound in Medicine

JF - Journal of Ultrasound in Medicine

SN - 0278-4297

IS - 9

ER -