Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years

R. Duara, R. A. Margolin, E. A. Robertson-Tchabo, E. D. London, M. Schwartz, J. W. Renfrew, B. J. Koziarz, M. Sundaram, C. Grady, A. M. Moore

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

Positron emission tomography (PET) scanning with 18F-2-deoxy-D-glucose was employed to examine hemispheric and regional rates of cerebral glucose utilization in 21 resting healthy men between the ages of 21 and 83 years. The eyes of the subjects were covered and the external auditory canals were plugged with cotton in the 45 minutes following injection of tracer. Mean hemispheric cerebral metabolic rates for glucose (CMR(glc)) averaged 4.3 to 4.4 mg.100 g-1.min-1, and mean hemispheric grey matter glucose utilization, (CMR(glc))(grey), averaged 5.2 to 5.3 mg.100 g-1.min-1. Neither parameter was correlated significantly with age, nor were their right/left ratios correlated with age (P > 0.05). The mean ratios, furthermore, did not differ significantly from 1. Regional cerebral metabolic rates for glucose, rCMR(glc), at each of 31 identified midline and bilateral structures also were not correlated significantly with age. Mean rCMR(glc) ranged from 2.6 mg.100 g-1.min-1 at the centrum semiovale to 6.2 mg.100 g-1.min-1 at the precentral gyrus of the frontal lobe and precuneus of the parietal lobe. The results indicate that the cerebral metabolic rate for glucose is not correlated with age in healthy men.

Original languageEnglish
Pages (from-to)761-775
Number of pages15
JournalBrain
Volume106
Issue number3
StatePublished - Nov 4 1983
Externally publishedYes

Fingerprint

positron-emission tomography
Positron Emission Tomography
Positron emission tomography
Glucose
Positron-Emission Tomography
glucose
Parietal Lobe
Frontal Lobe
Ear Canal
Deoxyglucose
Canals
Cotton
tracer techniques
Scanning
Injection
cotton
eyes
Injections
injection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Duara, R., Margolin, R. A., Robertson-Tchabo, E. A., London, E. D., Schwartz, M., Renfrew, J. W., ... Moore, A. M. (1983). Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. Brain, 106(3), 761-775.

Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. / Duara, R.; Margolin, R. A.; Robertson-Tchabo, E. A.; London, E. D.; Schwartz, M.; Renfrew, J. W.; Koziarz, B. J.; Sundaram, M.; Grady, C.; Moore, A. M.

In: Brain, Vol. 106, No. 3, 04.11.1983, p. 761-775.

Research output: Contribution to journalArticle

Duara, R, Margolin, RA, Robertson-Tchabo, EA, London, ED, Schwartz, M, Renfrew, JW, Koziarz, BJ, Sundaram, M, Grady, C & Moore, AM 1983, 'Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years', Brain, vol. 106, no. 3, pp. 761-775.
Duara R, Margolin RA, Robertson-Tchabo EA, London ED, Schwartz M, Renfrew JW et al. Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. Brain. 1983 Nov 4;106(3):761-775.
Duara, R. ; Margolin, R. A. ; Robertson-Tchabo, E. A. ; London, E. D. ; Schwartz, M. ; Renfrew, J. W. ; Koziarz, B. J. ; Sundaram, M. ; Grady, C. ; Moore, A. M. / Cerebral glucose utilization, as measured with positron emission tomography in 21 resting healthy men between the ages of 21 and 83 years. In: Brain. 1983 ; Vol. 106, No. 3. pp. 761-775.
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abstract = "Positron emission tomography (PET) scanning with 18F-2-deoxy-D-glucose was employed to examine hemispheric and regional rates of cerebral glucose utilization in 21 resting healthy men between the ages of 21 and 83 years. The eyes of the subjects were covered and the external auditory canals were plugged with cotton in the 45 minutes following injection of tracer. Mean hemispheric cerebral metabolic rates for glucose (CMR(glc)) averaged 4.3 to 4.4 mg.100 g-1.min-1, and mean hemispheric grey matter glucose utilization, (CMR(glc))(grey), averaged 5.2 to 5.3 mg.100 g-1.min-1. Neither parameter was correlated significantly with age, nor were their right/left ratios correlated with age (P > 0.05). The mean ratios, furthermore, did not differ significantly from 1. Regional cerebral metabolic rates for glucose, rCMR(glc), at each of 31 identified midline and bilateral structures also were not correlated significantly with age. Mean rCMR(glc) ranged from 2.6 mg.100 g-1.min-1 at the centrum semiovale to 6.2 mg.100 g-1.min-1 at the precentral gyrus of the frontal lobe and precuneus of the parietal lobe. The results indicate that the cerebral metabolic rate for glucose is not correlated with age in healthy men.",
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AU - Margolin, R. A.

AU - Robertson-Tchabo, E. A.

AU - London, E. D.

AU - Schwartz, M.

AU - Renfrew, J. W.

AU - Koziarz, B. J.

AU - Sundaram, M.

AU - Grady, C.

AU - Moore, A. M.

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N2 - Positron emission tomography (PET) scanning with 18F-2-deoxy-D-glucose was employed to examine hemispheric and regional rates of cerebral glucose utilization in 21 resting healthy men between the ages of 21 and 83 years. The eyes of the subjects were covered and the external auditory canals were plugged with cotton in the 45 minutes following injection of tracer. Mean hemispheric cerebral metabolic rates for glucose (CMR(glc)) averaged 4.3 to 4.4 mg.100 g-1.min-1, and mean hemispheric grey matter glucose utilization, (CMR(glc))(grey), averaged 5.2 to 5.3 mg.100 g-1.min-1. Neither parameter was correlated significantly with age, nor were their right/left ratios correlated with age (P > 0.05). The mean ratios, furthermore, did not differ significantly from 1. Regional cerebral metabolic rates for glucose, rCMR(glc), at each of 31 identified midline and bilateral structures also were not correlated significantly with age. Mean rCMR(glc) ranged from 2.6 mg.100 g-1.min-1 at the centrum semiovale to 6.2 mg.100 g-1.min-1 at the precentral gyrus of the frontal lobe and precuneus of the parietal lobe. The results indicate that the cerebral metabolic rate for glucose is not correlated with age in healthy men.

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