Cerebral endothelial microvilli: Formation following global forebrain ischemia

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Scanning electron microscopy (SEM) and morphometric procedures designed to survey large areas of intraparenchymal vasculature disclosed the widespread production of cerebral endothelial microvilli following global ischemia of the rat forebrain. Although these surface projections were present, they were infrequent, in sham-operated controls. As little as 10 minutes of ischemia produced endothelial microvilli, which increased progressively in number with longer periods of ischemia. Transmission electron microscopy (TEM) performed on adjacent serial Vibratome sections confirmed these vascular alterations, although TEM sections did not permit an assessment of their numbers. Endothelial microvilli remained prominent in rats with up to 4 hours of postischemic recirculation. With SEM, these microvilli were sufficiently numerous so as to suggest that they may play a role in the development of the postischemic hypoperfusion documented by regional cerebral blood flow methods in this and other models of global cerebral ischemia.

Original languageEnglish
Pages (from-to)72-83
Number of pages12
JournalJournal of Neuropathology and Experimental Neurology
Volume43
Issue number1
StatePublished - Jan 1 1984

Fingerprint

Microvilli
Prosencephalon
Ischemia
Transmission Electron Microscopy
Electron Scanning Microscopy
Cerebrovascular Circulation
Regional Blood Flow
Brain Ischemia
Blood Vessels

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

@article{ff4742c6589346538036c18834ae79d4,
title = "Cerebral endothelial microvilli: Formation following global forebrain ischemia",
abstract = "Scanning electron microscopy (SEM) and morphometric procedures designed to survey large areas of intraparenchymal vasculature disclosed the widespread production of cerebral endothelial microvilli following global ischemia of the rat forebrain. Although these surface projections were present, they were infrequent, in sham-operated controls. As little as 10 minutes of ischemia produced endothelial microvilli, which increased progressively in number with longer periods of ischemia. Transmission electron microscopy (TEM) performed on adjacent serial Vibratome sections confirmed these vascular alterations, although TEM sections did not permit an assessment of their numbers. Endothelial microvilli remained prominent in rats with up to 4 hours of postischemic recirculation. With SEM, these microvilli were sufficiently numerous so as to suggest that they may play a role in the development of the postischemic hypoperfusion documented by regional cerebral blood flow methods in this and other models of global cerebral ischemia.",
author = "{Dalton Dietrich}, W. and R. Busto and Myron Ginsberg",
year = "1984",
month = "1",
day = "1",
language = "English",
volume = "43",
pages = "72--83",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Cerebral endothelial microvilli

T2 - Formation following global forebrain ischemia

AU - Dalton Dietrich, W.

AU - Busto, R.

AU - Ginsberg, Myron

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Scanning electron microscopy (SEM) and morphometric procedures designed to survey large areas of intraparenchymal vasculature disclosed the widespread production of cerebral endothelial microvilli following global ischemia of the rat forebrain. Although these surface projections were present, they were infrequent, in sham-operated controls. As little as 10 minutes of ischemia produced endothelial microvilli, which increased progressively in number with longer periods of ischemia. Transmission electron microscopy (TEM) performed on adjacent serial Vibratome sections confirmed these vascular alterations, although TEM sections did not permit an assessment of their numbers. Endothelial microvilli remained prominent in rats with up to 4 hours of postischemic recirculation. With SEM, these microvilli were sufficiently numerous so as to suggest that they may play a role in the development of the postischemic hypoperfusion documented by regional cerebral blood flow methods in this and other models of global cerebral ischemia.

AB - Scanning electron microscopy (SEM) and morphometric procedures designed to survey large areas of intraparenchymal vasculature disclosed the widespread production of cerebral endothelial microvilli following global ischemia of the rat forebrain. Although these surface projections were present, they were infrequent, in sham-operated controls. As little as 10 minutes of ischemia produced endothelial microvilli, which increased progressively in number with longer periods of ischemia. Transmission electron microscopy (TEM) performed on adjacent serial Vibratome sections confirmed these vascular alterations, although TEM sections did not permit an assessment of their numbers. Endothelial microvilli remained prominent in rats with up to 4 hours of postischemic recirculation. With SEM, these microvilli were sufficiently numerous so as to suggest that they may play a role in the development of the postischemic hypoperfusion documented by regional cerebral blood flow methods in this and other models of global cerebral ischemia.

UR - http://www.scopus.com/inward/record.url?scp=0021354803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021354803&partnerID=8YFLogxK

M3 - Article

C2 - 6693929

AN - SCOPUS:0021354803

VL - 43

SP - 72

EP - 83

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 1

ER -