Cerebral endothelial microvilli: Formation following global forebrain ischemia

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86 Scopus citations


Scanning electron microscopy (SEM) and morphometric procedures designed to survey large areas of intraparenchymal vasculature disclosed the widespread production of cerebral endothelial microvilli following global ischemia of the rat forebrain. Although these surface projections were present, they were infrequent, in sham-operated controls. As little as 10 minutes of ischemia produced endothelial microvilli, which increased progressively in number with longer periods of ischemia. Transmission electron microscopy (TEM) performed on adjacent serial Vibratome sections confirmed these vascular alterations, although TEM sections did not permit an assessment of their numbers. Endothelial microvilli remained prominent in rats with up to 4 hours of postischemic recirculation. With SEM, these microvilli were sufficiently numerous so as to suggest that they may play a role in the development of the postischemic hypoperfusion documented by regional cerebral blood flow methods in this and other models of global cerebral ischemia.

Original languageEnglish (US)
Pages (from-to)72-83
Number of pages12
JournalJournal of Neuropathology and Experimental Neurology
Issue number1
StatePublished - Jan 1984


  • Endothelial microvilli
  • Global cerebral ischemia
  • Micro vasculature
  • Postischemic cerebral hypoperfusion
  • Scanning electron microscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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