Az agyödéma és az agyi vértérfogat változása koponyasérült betegekben.

Translated title of the contribution: Cerebral edema and changes of cerebral blood volume in patients with head injuries

Pál Barzó, Anthony Marmarou, Panos Fatouros, Gennarina Portella, Andrea Czigner, Ross Bullock, Harold Young

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

AIM: The pathogenesis of traumatic brain swelling remains unclear. The generally held view is that brain swelling is caused primarily by vascular engorgement and that edema plays a relatively minor role in the swelling process. The goal of this study was to examine the roles of cerebral blood volume (CBV) and edema in traumatic brain swelling. PATIENTS AND METHODS: Both brain-tissue water and CBV were measured in 76 head-injured patients, and the relative contribution of edema and blood to total brain swelling was determined. Comparable measures of brain-tissue water were obtained in 30 healthy volunteers and CBV in seven volunteers. Brain edema was measured using magnetic resonance imaging, implementing a new technique for accurate measurement of total tissue water. Measurements of CBV in subgroup of 31 head-injured patients were based on consecutive measures of cerebral blood flow (CBF) obtained using stable xenon and calculation of mean transit time by dynamic computerized tomography scanning after a rapid bolus injection of iodinated contrast material. RESULTS: The mean (+/- standard deviation) percentage of swelling due to water was 9.37 +/- 8.7%, whereas that due to blood was -0.8 +/- 1.32%. CONCLUSION: The results of this study showed that brain edema is the major fluid component contributing to traumatic brain swelling. Moreover, CBV is reduced in proportion to CBF reduction following severe brain injury.

Original languageUndefined/Unknown
Pages (from-to)1625-1634
Number of pages10
JournalOrvosi Hetilap
Volume143
Issue number27
StatePublished - Jul 7 2002
Externally publishedYes

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Brain Edema
Craniocerebral Trauma
Cerebrovascular Circulation
Edema
Water
Head
Xenon
Brain
Cerebral Blood Volume
Brain Injuries
Contrast Media
Blood Vessels
Volunteers
Healthy Volunteers
Tomography
Magnetic Resonance Imaging
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Barzó, P., Marmarou, A., Fatouros, P., Portella, G., Czigner, A., Bullock, R., & Young, H. (2002). Az agyödéma és az agyi vértérfogat változása koponyasérült betegekben. Orvosi Hetilap, 143(27), 1625-1634.

Az agyödéma és az agyi vértérfogat változása koponyasérült betegekben. / Barzó, Pál; Marmarou, Anthony; Fatouros, Panos; Portella, Gennarina; Czigner, Andrea; Bullock, Ross; Young, Harold.

In: Orvosi Hetilap, Vol. 143, No. 27, 07.07.2002, p. 1625-1634.

Research output: Contribution to journalArticle

Barzó, P, Marmarou, A, Fatouros, P, Portella, G, Czigner, A, Bullock, R & Young, H 2002, 'Az agyödéma és az agyi vértérfogat változása koponyasérült betegekben.', Orvosi Hetilap, vol. 143, no. 27, pp. 1625-1634.
Barzó P, Marmarou A, Fatouros P, Portella G, Czigner A, Bullock R et al. Az agyödéma és az agyi vértérfogat változása koponyasérült betegekben. Orvosi Hetilap. 2002 Jul 7;143(27):1625-1634.
Barzó, Pál ; Marmarou, Anthony ; Fatouros, Panos ; Portella, Gennarina ; Czigner, Andrea ; Bullock, Ross ; Young, Harold. / Az agyödéma és az agyi vértérfogat változása koponyasérült betegekben. In: Orvosi Hetilap. 2002 ; Vol. 143, No. 27. pp. 1625-1634.
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abstract = "AIM: The pathogenesis of traumatic brain swelling remains unclear. The generally held view is that brain swelling is caused primarily by vascular engorgement and that edema plays a relatively minor role in the swelling process. The goal of this study was to examine the roles of cerebral blood volume (CBV) and edema in traumatic brain swelling. PATIENTS AND METHODS: Both brain-tissue water and CBV were measured in 76 head-injured patients, and the relative contribution of edema and blood to total brain swelling was determined. Comparable measures of brain-tissue water were obtained in 30 healthy volunteers and CBV in seven volunteers. Brain edema was measured using magnetic resonance imaging, implementing a new technique for accurate measurement of total tissue water. Measurements of CBV in subgroup of 31 head-injured patients were based on consecutive measures of cerebral blood flow (CBF) obtained using stable xenon and calculation of mean transit time by dynamic computerized tomography scanning after a rapid bolus injection of iodinated contrast material. RESULTS: The mean (+/- standard deviation) percentage of swelling due to water was 9.37 +/- 8.7{\%}, whereas that due to blood was -0.8 +/- 1.32{\%}. CONCLUSION: The results of this study showed that brain edema is the major fluid component contributing to traumatic brain swelling. Moreover, CBV is reduced in proportion to CBF reduction following severe brain injury.",
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