Cerebral blood flow measurement as an indicator of the haemodynamic severity of carotid artery disease in man

Ross Bullock, A. D. Mendelow, J. Patterson, I. Bone

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The non-invasive xenon-133 inhalation technique was used to measure regional cerebral blood flow in 61 patients with cerebrovascular disease in whom carotid angiography had been performed before carotid endarterectomy or extracranial/intracranial arterial bypass were considered. Hemispheric cerebral blood flow (CBF) was significantly lower in patients with an ipsilateral internal carotid artery occlusion than in those with a patent vessel. CBF values were also influenced by disease of the contralateral carotid artery. The cerebrovascular response to hypercapnia was a more sensitive index of carotid disease; a significant reduction in CO2 responsiveness was found both with occlusion and stenosis of the ipsilateral internal carotid artery. These data suggest that CBF measurements may be clinically useful in selecting patients for angiography and surgery.

Original languageEnglish
Pages (from-to)429-431
Number of pages3
JournalSouth African Medical Journal
Volume65
Issue number11
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Carotid Artery Diseases
Hemodynamics
Angiography
Cerebral Revascularization
Cerebrovascular Disorders
Xenon
Hypercapnia
Carotid Endarterectomy
Carotid Stenosis
Regional Blood Flow
Internal Carotid Artery
Inhalation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cerebral blood flow measurement as an indicator of the haemodynamic severity of carotid artery disease in man. / Bullock, Ross; Mendelow, A. D.; Patterson, J.; Bone, I.

In: South African Medical Journal, Vol. 65, No. 11, 01.01.1984, p. 429-431.

Research output: Contribution to journalArticle

Bullock, Ross ; Mendelow, A. D. ; Patterson, J. ; Bone, I. / Cerebral blood flow measurement as an indicator of the haemodynamic severity of carotid artery disease in man. In: South African Medical Journal. 1984 ; Vol. 65, No. 11. pp. 429-431.
@article{b7ff0457ba514d07ae1a5128970f94c1,
title = "Cerebral blood flow measurement as an indicator of the haemodynamic severity of carotid artery disease in man",
abstract = "The non-invasive xenon-133 inhalation technique was used to measure regional cerebral blood flow in 61 patients with cerebrovascular disease in whom carotid angiography had been performed before carotid endarterectomy or extracranial/intracranial arterial bypass were considered. Hemispheric cerebral blood flow (CBF) was significantly lower in patients with an ipsilateral internal carotid artery occlusion than in those with a patent vessel. CBF values were also influenced by disease of the contralateral carotid artery. The cerebrovascular response to hypercapnia was a more sensitive index of carotid disease; a significant reduction in CO2 responsiveness was found both with occlusion and stenosis of the ipsilateral internal carotid artery. These data suggest that CBF measurements may be clinically useful in selecting patients for angiography and surgery.",
author = "Ross Bullock and Mendelow, {A. D.} and J. Patterson and I. Bone",
year = "1984",
month = "1",
day = "1",
language = "English",
volume = "65",
pages = "429--431",
journal = "South African Medical Journal",
issn = "0038-2469",
publisher = "South African Medical Association",
number = "11",

}

TY - JOUR

T1 - Cerebral blood flow measurement as an indicator of the haemodynamic severity of carotid artery disease in man

AU - Bullock, Ross

AU - Mendelow, A. D.

AU - Patterson, J.

AU - Bone, I.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - The non-invasive xenon-133 inhalation technique was used to measure regional cerebral blood flow in 61 patients with cerebrovascular disease in whom carotid angiography had been performed before carotid endarterectomy or extracranial/intracranial arterial bypass were considered. Hemispheric cerebral blood flow (CBF) was significantly lower in patients with an ipsilateral internal carotid artery occlusion than in those with a patent vessel. CBF values were also influenced by disease of the contralateral carotid artery. The cerebrovascular response to hypercapnia was a more sensitive index of carotid disease; a significant reduction in CO2 responsiveness was found both with occlusion and stenosis of the ipsilateral internal carotid artery. These data suggest that CBF measurements may be clinically useful in selecting patients for angiography and surgery.

AB - The non-invasive xenon-133 inhalation technique was used to measure regional cerebral blood flow in 61 patients with cerebrovascular disease in whom carotid angiography had been performed before carotid endarterectomy or extracranial/intracranial arterial bypass were considered. Hemispheric cerebral blood flow (CBF) was significantly lower in patients with an ipsilateral internal carotid artery occlusion than in those with a patent vessel. CBF values were also influenced by disease of the contralateral carotid artery. The cerebrovascular response to hypercapnia was a more sensitive index of carotid disease; a significant reduction in CO2 responsiveness was found both with occlusion and stenosis of the ipsilateral internal carotid artery. These data suggest that CBF measurements may be clinically useful in selecting patients for angiography and surgery.

UR - http://www.scopus.com/inward/record.url?scp=0021344087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021344087&partnerID=8YFLogxK

M3 - Article

C2 - 6701703

AN - SCOPUS:0021344087

VL - 65

SP - 429

EP - 431

JO - South African Medical Journal

JF - South African Medical Journal

SN - 0038-2469

IS - 11

ER -