Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis

Makoto Tanaka, Susumu Kondo, Shunsaku Hirai, Xiaoyan Sun, Takayuki Yamagishi, Koichi Okamoto

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We examined regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) in 4 patients with progressive dementia associated with amyotrophic lateral sclerosis (ALS), in 9 patients with classical ALS without dementia, and in 13 normal controls, using positron emission tomography with oxygen-15 gas and oxygen-15 labeled carbon dioxide. The mean rCBF and rCMRO2 in the anterior cerebral hemispheres decreased significantly in patients with progressive dementia with ALS, compared to those in controls. Patients with only ALS showed very mild reductions of rCBF and rCMRO2 which were not statistically significant. These data suggest that hypoperfusion and oxygen hypometabolism in the anterior cerebral hemispheres have an etiological relationship to deterioration of intellect in patients with progressive dementia with ALS. A significant reduction in the mean rCBF was also found in the cerebellar hemispheres in progressive dementia with ALS, while a reduction of mean rCMRO2 was not significant. Remote effects analoguos to crossed cerebellar diaschisis occurring bilaterally were assumed to explain the cerebellar hypoperfusion.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalJournal of the Neurological Sciences
Volume120
Issue number1
DOIs
StatePublished - Dec 1 1993
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Amyotrophic Lateral Sclerosis
Regional Blood Flow
Oxygen
Cerebrum
Dementia
Carbon Dioxide
Positron-Emission Tomography
Gases

Keywords

  • Amyotrophic lateral sclerosis
  • Cerebral blood flow
  • Cerebral oxygen metabolism
  • Motor neuron disease
  • Positron emission tomography
  • Progressive dementia

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis. / Tanaka, Makoto; Kondo, Susumu; Hirai, Shunsaku; Sun, Xiaoyan; Yamagishi, Takayuki; Okamoto, Koichi.

In: Journal of the Neurological Sciences, Vol. 120, No. 1, 01.12.1993, p. 22-28.

Research output: Contribution to journalArticle

Tanaka, Makoto ; Kondo, Susumu ; Hirai, Shunsaku ; Sun, Xiaoyan ; Yamagishi, Takayuki ; Okamoto, Koichi. / Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis. In: Journal of the Neurological Sciences. 1993 ; Vol. 120, No. 1. pp. 22-28.
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