Cerebral arteriolar damage by arachidonic acid and prostaglandin G 2

Hermes A. Kontos; Enoch P. Wei; John T. Povlishock; W. Dalton Dietrich; Christopher J. Magiera; Earl F. Ellis

doi:10.1126/science.7403881

Cerebral arteriolar damage by arachidonic acid and prostaglandin G ₂

Hermes A. Kontos, Enoch P. Wei, John T. Povlishock, W. Dalton Dietrich, Christopher J. Magiera, Earl F. Ellis

Research output: Contribution to journal › Article

168 Scopus citations

Abstract

Application of arachidonic acid or prostaglandin G₂ to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H₂, prostaglandin E₂, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

Original language	English (US)
Pages (from-to)	1242-1245
Number of pages	4
Journal	Science
Volume	209
Issue number	4462
DOIs	https://doi.org/10.1126/science.7403881
State	Published - Jan 1 1980
Externally published	Yes

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Kontos, H. A., Wei, E. P., Povlishock, J. T., Dalton Dietrich, W., Magiera, C. J., & Ellis, E. F. (1980). Cerebral arteriolar damage by arachidonic acid and prostaglandin G ₂. Science, 209(4462), 1242-1245. https://doi.org/10.1126/science.7403881

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