Cerebral arteriolar damage by arachidonic acid and prostaglandin G 2

Hermes A. Kontos, Enoch P. Wei, John T. Povlishock, W. Dalton Dietrich, Christopher J. Magiera, Earl F. Ellis

Research output: Contribution to journalArticle

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Abstract

Application of arachidonic acid or prostaglandin G2 to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H2, prostaglandin E2, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

Original languageEnglish (US)
Pages (from-to)1242-1245
Number of pages4
JournalScience
Volume209
Issue number4462
DOIs
StatePublished - Jan 1 1980
Externally publishedYes

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    Kontos, H. A., Wei, E. P., Povlishock, J. T., Dalton Dietrich, W., Magiera, C. J., & Ellis, E. F. (1980). Cerebral arteriolar damage by arachidonic acid and prostaglandin G 2. Science, 209(4462), 1242-1245. https://doi.org/10.1126/science.7403881