Cerebral arteriolar damage by arachidonic acid and prostaglandin G 2

Hermes A. Kontos; Enoch P. Wei; John T. Povlishock; W. Dalton Dietrich; Christopher J. Magiera; Earl F. Ellis

doi:10.1126/science.7403881

Cerebral arteriolar damage by arachidonic acid and prostaglandin G ₂

Hermes A. Kontos, Enoch P. Wei, John T. Povlishock, W. Dalton Dietrich, Christopher J. Magiera, Earl F. Ellis

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Abstract

Application of arachidonic acid or prostaglandin G₂ to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H₂, prostaglandin E₂, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

Original language	English (US)
Pages (from-to)	1242-1245
Number of pages	4
Journal	Science
Volume	209
Issue number	4462
DOIs	https://doi.org/10.1126/science.7403881
State	Published - Jan 1 1980
Externally published	Yes

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title = "Cerebral arteriolar damage by arachidonic acid and prostaglandin G 2",

abstract = "Application of arachidonic acid or prostaglandin G2 to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H2, prostaglandin E2, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.",

author = "Kontos, {Hermes A.} and Wei, {Enoch P.} and Povlishock, {John T.} and {Dalton Dietrich}, W. and Magiera, {Christopher J.} and Ellis, {Earl F.}",

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AU - Kontos, Hermes A.

AU - Wei, Enoch P.

AU - Povlishock, John T.

AU - Dalton Dietrich, W.

AU - Magiera, Christopher J.

AU - Ellis, Earl F.

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N2 - Application of arachidonic acid or prostaglandin G2 to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H2, prostaglandin E2, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

AB - Application of arachidonic acid or prostaglandin G2 to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H2, prostaglandin E2, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

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Cerebral arteriolar damage by arachidonic acid and prostaglandin G ₂

Abstract

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