Cerebral arteriolar damage by arachidonic acid and prostaglandin G 2

Hermes A. Kontos; Enoch P. Wei; John T. Povlishock; W. Dalton Dietrich; Christopher J. Magiera; Earl F. Ellis

doi:10.1126/science.7403881

Cerebral arteriolar damage by arachidonic acid and prostaglandin G ₂

Hermes A. Kontos, Enoch P. Wei, John T. Povlishock, W. Dalton Dietrich, Christopher J. Magiera, Earl F. Ellis

Research output: Contribution to journal › Article › peer-review

169 Scopus citations

Abstract

Application of arachidonic acid or prostaglandin G₂ to the brain surface of anesthetized cats induced cerebral arteriolar damage. Scavengers of free oxygen radicals inhibited this damage. Prostaglandin H₂, prostaglandin E₂, and 11,14,17-eicosatrienoic acid did not produce arteriolar damage. It appears that increased prostaglandin synthesis produces cerebral vascular damage by generating free oxygen radicals.

Original language	English (US)
Pages (from-to)	1242-1245
Number of pages	4
Journal	Science
Volume	209
Issue number	4462
DOIs	https://doi.org/10.1126/science.7403881
State	Published - Jan 1 1980
Externally published	Yes

ASJC Scopus subject areas

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AU - Magiera, Christopher J.

AU - Ellis, Earl F.

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