Centrally administered neurotensin: Activity in the Julou-Courvoisier muscle relaxation test in mice

Albert J. Osbahr; Charles Nemeroff; Paul J. Manberg; Arthur J. Prange

doi:10.1016/0014-2999(79)90090-6

Centrally administered neurotensin: Activity in the Julou-Courvoisier muscle relaxation test in mice

Albert J. Osbahr, Charles Nemeroff, Paul J. Manberg, Arthur J. Prange

Research output: Contribution to journal › Article

48 Scopus citations

Abstract

Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects of NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.

Original language	English
Pages (from-to)	299-302
Number of pages	4
Journal	European Journal of Pharmacology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(79)90090-6
State	Published - Mar 1 1979
Externally published	Yes

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Keywords

Neuroleptic
Neurotensin
Peptides
Thyrotropin-releasing hormone

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

Cite this

Osbahr, A. J., Nemeroff, C., Manberg, P. J., & Prange, A. J. (1979). Centrally administered neurotensin: Activity in the Julou-Courvoisier muscle relaxation test in mice. European Journal of Pharmacology, 54(3), 299-302. https://doi.org/10.1016/0014-2999(79)90090-6

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10.1016/0014-2999(79)90090-6