Centrally administered neurotensin: Activity in the Julou-Courvoisier muscle relaxation test in mice

Albert J. Osbahr, Charles Nemeroff, Paul J. Manberg, Arthur J. Prange

Research output: Contribution to journalArticle

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Abstract

Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects of NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalEuropean Journal of Pharmacology
Volume54
Issue number3
DOIs
StatePublished - Mar 1 1979
Externally publishedYes

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Keywords

  • Neuroleptic
  • Neurotensin
  • Peptides
  • Thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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