Abstract
Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects of NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 299-302 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 54 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 1979 |
| Externally published | Yes |
Keywords
- Neuroleptic
- Neurotensin
- Peptides
- Thyrotropin-releasing hormone
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
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Osbahr, A. J., Nemeroff, C. B., Manberg, P. J., & Prange, A. J. (1979). Centrally administered neurotensin: Activity in the Julou-Courvoisier muscle relaxation test in mice. European Journal of Pharmacology, 54(3), 299-302. https://doi.org/10.1016/0014-2999(79)90090-6