TY - JOUR
T1 - Centrally administered neurotensin
T2 - Activity in the Julou-Courvoisier muscle relaxation test in mice
AU - Osbahr, Albert J.
AU - Nemeroff, Charles B.
AU - Manberg, Paul J.
AU - Prange, Arthur J.
PY - 1979/3/1
Y1 - 1979/3/1
N2 - Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects of NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.
AB - Intracisternal (IC) neurotensin (NT) produces muscle relaxation in the Julou-Courvoisier traction test, a screening procedure utilized for assessing neuroleptic drug activity. A dose-response relationship was not observed. IC administration of thyrotropin-releasing hormone (TRH) totally abolished the effects of NT. Two other peptides, substance P and bradykinin, were inactive in the traction test. These data provide further evidence for CNS effects of NT and indicate that this peptide exerts neuroleptic-like activity in a screening test for antipsychotic agents.
KW - Neuroleptic
KW - Neurotensin
KW - Peptides
KW - Thyrotropin-releasing hormone
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U2 - 10.1016/0014-2999(79)90090-6
DO - 10.1016/0014-2999(79)90090-6
M3 - Article
C2 - 107032
AN - SCOPUS:0018374754
VL - 54
SP - 299
EP - 302
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -