Central serotoninergic stimulation by fenfluramine challenge does not affect plasma thyrotropin-stimulating hormone levels in man

Emil F. Coccaro, Larry J. Siever, Ione A. Kourides, Federico Adan, Gordon Campbell, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Thyrotropin-stimulating hormone (TSH) and prolactin (PRL) responses to an acute oral challenge of fenfluramine (60 mg), a central serotoninergic (5-hydroxytryptamine) releasing/uptake inhibiting agent, were examined in 8 healthy males in order to assess the role of central serotoninergic stimulation in the release of TSH. Plasma PRL, but not TSH, was significantly elevated by fenfluramine. These data suggest that central serotoninergic activity does not play an important role in the physiologic release of plasma TSH in man. Further, thyrotropin-releasing hormone is unlikely to be the PRL-releasing factor involved in the fenfluramine-induced stimulation of PRL.

Original languageEnglish (US)
Pages (from-to)273-276
Number of pages4
JournalNeuroendocrinology
Volume47
Issue number4
DOIs
StatePublished - 1988

Keywords

  • 5-Hydroxytryptamine
  • Prolactin
  • Thyrotropin-stimulating hormone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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