Central pontine myelinolysis: two cases with associated electrolyte disturbance

B. E. Tomlinson, A. M. Pierides, W. G. Bradley

Research output: Chapter in Book/Report/Conference proceedingChapter

143 Scopus citations

Abstract

Two patients with central pontine myelinolysis are described. Both were middle aged women presenting with a history of protracted vomiting and drowsiness. Hyponatremia (serum sodium 96 to 100 mmol/L) was a feature in both patients. No underlying malignancy, alcoholism, malnutrition or other serious disease was identified. Correction of electrolyte abnormalities was accompanied by deterioration in level of consciousness and development of a neurologic syndrome characterized by quadriparesis, dysphasia and mutism. Death followed and histopathologic examination confirmed classical myelinolysis in the central pons and extensive similar, though not identical, lesions in the cerebral hemispheres in both cases. The pathophysiologic basis of the lesions is likely to be a special metabolic susceptibility of oligodendroglial cells in areas where neurones, glial cells and myelin sheaths lie in close proximity to one another.

Original languageEnglish
Title of host publicationQuarterly Journal of Medicine
Pages373-386
Number of pages14
Volume45
Edition179
StatePublished - Dec 1 1976
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Tomlinson, B. E., Pierides, A. M., & Bradley, W. G. (1976). Central pontine myelinolysis: two cases with associated electrolyte disturbance. In Quarterly Journal of Medicine (179 ed., Vol. 45, pp. 373-386)