Central pontine myelinolysis: Historical and mechanistic considerations

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Central pontine myelinolysis (CPM) is a demyelinating condition affecting not only the pontine base, but also involving other brain areas. It usually occurs on a background of chronic systemic illness, and is commonly observed in individuals with alcoholism, malnutrition and liver disease. Studies carried out 25-30 years ago established that the principal etiological factor was the rapid correction of hyponatremia resulting in osmotic stress. This article reviews progress achieved since that time on its pathogenesis, focusing on the role of organic osmolytes, the blood-brain, barrier, endothelial cells, myelinotoxic factors triggered by osmotic stress, and the role of various factors that predispose to the development of CPM. These advances show great promise in providing novel therapeutic options for the management of patients afflicted with CPM.

Original languageEnglish
Pages (from-to)97-106
Number of pages10
JournalMetabolic Brain Disease
Volume25
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Central Pontine Myelinolysis
Osmotic Pressure
Endothelial cells
Liver
Brain
Hyponatremia
Blood-Brain Barrier
Malnutrition
Alcoholism
Liver Diseases
Chronic Disease
Endothelial Cells
Therapeutics

Keywords

  • Apoptosis
  • Blood-brain barrier
  • Central pontine myelinolysis
  • Demyelination
  • Endothelial cells
  • Hepatic encephalopathy
  • Hyponatremia
  • Organic osmolytes
  • Osmotic stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Central pontine myelinolysis : Historical and mechanistic considerations. / Norenberg, Michael D.

In: Metabolic Brain Disease, Vol. 25, No. 1, 01.03.2010, p. 97-106.

Research output: Contribution to journalArticle

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