Central obesity, leptin and cognitive decline: The sacramento area Latino study on aging

Adina Zeki Al Hazzouri, Mary N. Haan, Rachel A. Whitmer, Kristine Yaffe, John Neuhaus

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Background/Aims: Central obesity is a risk factor for cognitive decline. Leptin is secreted by adipose tissue and has been associated with better cognitive function. Aging Mexican Americans have higher levels of obesity than non-Hispanic Whites, but no investigations examined the relationship between leptin and cognitive decline among them or the role of central obesity in this association. Methods: We analyzed 1,480 dementia-free older Mexican Americans who were followed over 10 years. Cognitive function was assessed every 12-15 months with the Modified Mini Mental State Exam (3MSE) and the Spanish and English Verbal Learning Test (SEVLT). Results: For females with a small waist circumference (≤35 inches), an interquartile range difference in leptin was associated with 35% less 3MSE errors and 22% less decline in the SEVLT score over 10 years. For males with a small waist circumference (≤40 inches), an interquartile range difference in leptin was associated with 44% less 3MSE errors and 30% less decline in the SEVLT score over 10 years. There was no association between leptin and cognitive decline among females or males with a large waist circumference. Conclusion: Leptin interacts with central obesity in shaping cognitive decline. Our findings provide valuable information about the effects of metabolic risk factors on cognitive function.

Original languageEnglish (US)
Pages (from-to)400-409
Number of pages10
JournalDementia and Geriatric Cognitive Disorders
Volume33
Issue number6
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Keywords

  • Aging
  • Cognition
  • Leptin
  • Longitudinal study
  • Mexican Americans
  • Obesity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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