Central nervous system pharmacokinetics of high-dose cytosine arabinoside

Jose A. Lopez, Edgard Nassif, Paula Vannicola, John G. Krikorian, Ram P. Agarwal

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

The cerebrospinal fluid (CSF) pharmacokinetics of cytosine arabinoside (Ara-C) was determined in 8 patients with metastatic cancer in the central nervous system. High dose (3 gm/M2) one-hour intravenous infusions of Ara-C were given with serial CSF sampling obtained from indwelling Ommaya reservoirs. CSF was analyzed by high pressure liquid chromatography. Mean Ara-C elimination half life of 140 minutes in CSF was eight times longer than that in plasma. The peak mean CSF concentration of Ara-C (2.l ug/ml) was about 7% of the plasma concentration (30 ug/ml). A total of 28 treatment courses were administered with minimal hematopoietic, gastrointestinal and neurological toxicities. A schedule of administration of 2 high-dose treatments 12 hours apart repeated every two weeks should maintain cytotoxic CSF concentrations which could prove useful in the management of CNS leukemia and lymphoma.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalJournal of neuro-oncology
Volume3
Issue number2
DOIs
StatePublished - Jun 1 1985

Keywords

  • CNS pharmacolocy of high dose Ara-C

ASJC Scopus subject areas

  • Neuroscience(all)
  • Oncology
  • Clinical Neurology
  • Cancer Research

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  • Cite this

    Lopez, J. A., Nassif, E., Vannicola, P., Krikorian, J. G., & Agarwal, R. P. (1985). Central nervous system pharmacokinetics of high-dose cytosine arabinoside. Journal of neuro-oncology, 3(2), 119-124. https://doi.org/10.1007/BF02228887