Central nervous system manifestations of marginal zone B-cell lymphoma

Soley Bayraktar, Alexandra Stefanovic, Naomi Montague, Janet L Davis, Timothy Murray, Izidore Lossos

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Primary or secondary central nervous system (CNS) involvement by marginal zone B-cell lymphoma (MZBCL) is rare. A retrospective analysis of patients was done with MZBCL involving the CNS, diagnosed and treated at our institution between 2004 and 2010. We identified 10 MZBCL patients with primary (six) or secondary (four) CNS involvement. Five patients presented with primary dural lymphoma and were treated with surgical resection, whole-brain radiation, or systemic chemotherapy. Only one patient had CNS relapse 5 years later. A single patient with primary intraocular lymphoma achieved clinical remission with ocular radiotherapy and systemic chemotherapy. Four patients had ocular MZBCL within 5 years of the initial diagnosis of primary ocular adnexal MZBCL and primary splenic MZBCL. There was no evidence of local recurrence in all but one who developed systemic relapse after 3 years of follow-up. Primary or secondary CNS involvement by MZBCL display indolent clinical behavior and have a generally favorable prognosis, underlining the importance of their differentiation from aggressive lymphomas that more commonly involve the CNS.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalAnnals of Hematology
Volume89
Issue number10
DOIs
StatePublished - Oct 1 2010

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Marginal Zone B-Cell Lymphoma
Central Nervous System
Recurrence
Lymphoma
Intraocular Lymphoma
Drug Therapy
Radiotherapy
Radiation
Brain

Keywords

  • Marginal zone B-cell lymphoma
  • Primary CNS lymphoma
  • Primary dural lymphoma
  • Primary intraocular lymphoma

ASJC Scopus subject areas

  • Hematology

Cite this

Central nervous system manifestations of marginal zone B-cell lymphoma. / Bayraktar, Soley; Stefanovic, Alexandra; Montague, Naomi; Davis, Janet L; Murray, Timothy; Lossos, Izidore.

In: Annals of Hematology, Vol. 89, No. 10, 01.10.2010, p. 1003-1009.

Research output: Contribution to journalArticle

Bayraktar, Soley ; Stefanovic, Alexandra ; Montague, Naomi ; Davis, Janet L ; Murray, Timothy ; Lossos, Izidore. / Central nervous system manifestations of marginal zone B-cell lymphoma. In: Annals of Hematology. 2010 ; Vol. 89, No. 10. pp. 1003-1009.
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