Abstract
Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice guidelines are lacking in the management of most central nervous system (CNS) complications in HM. Herein we review the pathophysiology, presentation and treatment of elevated intracranial pressure, spinal cord compression, status epilepticus, neurovascular complications, CNS infection, leucostasis and hyperviscosity. Further, we discuss the expanding spectrum of neurological complications of old and novel treatments in HM.
| Original language | English (US) |
|---|---|
| Journal | British Journal of Haematology |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- central nervous system
- emergencies
- haematological malignancies
ASJC Scopus subject areas
- Hematology
Cite this
Central nervous system emergencies in haematological malignancies. / de la Fuente, Macarena I.; Alderuccio, Juan Pablo; Lossos, Izidore S.
In: British Journal of Haematology, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Central nervous system emergencies in haematological malignancies
AU - de la Fuente, Macarena I.
AU - Alderuccio, Juan Pablo
AU - Lossos, Izidore S.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice guidelines are lacking in the management of most central nervous system (CNS) complications in HM. Herein we review the pathophysiology, presentation and treatment of elevated intracranial pressure, spinal cord compression, status epilepticus, neurovascular complications, CNS infection, leucostasis and hyperviscosity. Further, we discuss the expanding spectrum of neurological complications of old and novel treatments in HM.
AB - Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice guidelines are lacking in the management of most central nervous system (CNS) complications in HM. Herein we review the pathophysiology, presentation and treatment of elevated intracranial pressure, spinal cord compression, status epilepticus, neurovascular complications, CNS infection, leucostasis and hyperviscosity. Further, we discuss the expanding spectrum of neurological complications of old and novel treatments in HM.
KW - central nervous system
KW - emergencies
KW - haematological malignancies
UR - http://www.scopus.com/inward/record.url?scp=85071768827&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071768827&partnerID=8YFLogxK
U2 - 10.1111/bjh.16184
DO - 10.1111/bjh.16184
M3 - Review article
C2 - 31483060
AN - SCOPUS:85071768827
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
ER -