Central nervous system emergencies in haematological malignancies

Research output: Contribution to journalReview articlepeer-review


Neurological emergencies are frequently catastrophic events in the course of haematological malignancies (HM) that, if not promptly recognized and treated, may lead to lethal outcomes or chronic sequelae. They may occur at any time during the disease course, but are more frequently observed following relapse. Practice guidelines are lacking in the management of most central nervous system (CNS) complications in HM. Herein we review the pathophysiology, presentation and treatment of elevated intracranial pressure, spinal cord compression, status epilepticus, neurovascular complications, CNS infection, leucostasis and hyperviscosity. Further, we discuss the expanding spectrum of neurological complications of old and novel treatments in HM.

Original languageEnglish (US)
Pages (from-to)1028-1037
Number of pages10
JournalBritish Journal of Haematology
Issue number6
StatePublished - Jun 1 2020


  • central nervous system
  • emergencies
  • haematological malignancies

ASJC Scopus subject areas

  • Hematology


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