Central effects of atropine upon aversive classical conditioning in rabbits

D. Downs, C. Cardozo, Neil Schneiderman, A. L. Yehle, D. H. VanDercar, G. Zwilling

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Rabbits were given classical discrimination conditioning with one of two tones followed by shock. In Experiment I, 40 rabbits were trained under saline, 10, 18 or 26 mg/kg atropine sulfate or 18 mg/kg methylatropine. Six rabbits in Experiment 2 were conditioned, then given further sessions with saline, and 18, 26 and 34 mg/kg atropine sulfate and methylatropine. In Experiment 3, 18 rabbits were conditioned and then given two extinction sessions under saline or 34 mg/kg atropine sulfate or methylatropine followed by extinction under saline. Chief findings were (a) atropine sulfate but not methylatropine disrupted acquisition and maintenance of conditioned eyeblinks, (b) neither drug affected unconditioned blinks, (c) fewer blinks occurred in extinction under atropine sulfate than under methylatropine or saline, (d) rabbits extinguished under atropine sulphate showed higher percentages of eyeblinks when tested without drug. Disruptions in performance of learned eyeblink responses appeared to be due to drug interference with central cholinergic transmission.

Original languageEnglish
Pages (from-to)319-333
Number of pages15
JournalPsychopharmacologia
Volume23
Issue number4
DOIs
StatePublished - Dec 1 1972

Fingerprint

Classical Conditioning
Atropine
Rabbits
Pharmaceutical Preparations
Cholinergic Agents
Shock
Maintenance
methylatropine
Psychological Extinction

Keywords

  • Atropine Methylnitrate
  • Atropine Sulfate
  • Aversive Classical Conditioning
  • Differential Conditioning
  • Extinction
  • Rabbits

ASJC Scopus subject areas

  • Pharmacology

Cite this

Downs, D., Cardozo, C., Schneiderman, N., Yehle, A. L., VanDercar, D. H., & Zwilling, G. (1972). Central effects of atropine upon aversive classical conditioning in rabbits. Psychopharmacologia, 23(4), 319-333. https://doi.org/10.1007/BF00406735

Central effects of atropine upon aversive classical conditioning in rabbits. / Downs, D.; Cardozo, C.; Schneiderman, Neil; Yehle, A. L.; VanDercar, D. H.; Zwilling, G.

In: Psychopharmacologia, Vol. 23, No. 4, 01.12.1972, p. 319-333.

Research output: Contribution to journalArticle

Downs, D, Cardozo, C, Schneiderman, N, Yehle, AL, VanDercar, DH & Zwilling, G 1972, 'Central effects of atropine upon aversive classical conditioning in rabbits', Psychopharmacologia, vol. 23, no. 4, pp. 319-333. https://doi.org/10.1007/BF00406735
Downs, D. ; Cardozo, C. ; Schneiderman, Neil ; Yehle, A. L. ; VanDercar, D. H. ; Zwilling, G. / Central effects of atropine upon aversive classical conditioning in rabbits. In: Psychopharmacologia. 1972 ; Vol. 23, No. 4. pp. 319-333.
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