Central Corneal Thickness and Corneal Hysteresis During Corneal Swelling Induced by Contact Lens Wear With Eye Closure

Fan Lu, Suzhong Xu, Jia Qu, Meixiao Shen, Xiaoxing Wang, Haizhen Fang, Jianhua Wang

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine if corneal hysteresis (CH) was associated with increased central corneal thickness (CCT) induced by wearing soft contact lenses during eye closure. Design: A prospective laboratory investigation. Methods: CCT was measured with a modified optical coherence tomography (OCT), and CH was measured with a Reichert Ocular Response Analyzer (ORA) [Reichert Ophthalmic Instruments, Depew, New York, USA]. The ORA also determined values for intraocular pressure (IOP), corneal compensated IOP (IOPcc), and corneal resistance factor (CRF). One randomly selected eye of 20 non-contact lens wearers (four males and 16 females, age 19.7 ± 1.1 years) was patched during three hours of soft contact lens wear. Measurements were made before lens insertion, immediately upon removal, and every 20 minutes thereafter for 100 minutes. Results: Immediately after contact lens removal, CCT was increased by 13.1 ± 2.2% (mean ± SD) compared with baseline (post hoc, P = .001). After 100 minutes, it remained elevated by 2.4 ± 1.6% (post hoc, P = .001). However, there were no significant differences of CH at any time after lens wear (analysis of variance [ANOVA], P = .9). Immediately after lens removal, there were significant increases in IOP (post hoc, P = .003) and corneal resistance factor (CRF) (post-hoc, P = .015), but not in IOPcc (post hoc, P = .07). After lens wear, there were significant but weak correlations between the percentage change of CCT (CCT%) and IOP (r = 0.32, P = .001) and IOPcc (r = 0.29, P = .001). However, there was no significant correlation between CCT% and CH (r = 0.07, P = .458). Conclusion: CH as measured by ORA was not associated with corneal swelling induced by soft contact lens wear in this study group.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume143
Issue number4
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

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Contact Lenses
Lenses
Intraocular Pressure
Hydrophilic Contact Lens
R Factors
Optical Coherence Tomography
Analysis of Variance

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Central Corneal Thickness and Corneal Hysteresis During Corneal Swelling Induced by Contact Lens Wear With Eye Closure. / Lu, Fan; Xu, Suzhong; Qu, Jia; Shen, Meixiao; Wang, Xiaoxing; Fang, Haizhen; Wang, Jianhua.

In: American Journal of Ophthalmology, Vol. 143, No. 4, 01.04.2007.

Research output: Contribution to journalArticle

Lu, Fan ; Xu, Suzhong ; Qu, Jia ; Shen, Meixiao ; Wang, Xiaoxing ; Fang, Haizhen ; Wang, Jianhua. / Central Corneal Thickness and Corneal Hysteresis During Corneal Swelling Induced by Contact Lens Wear With Eye Closure. In: American Journal of Ophthalmology. 2007 ; Vol. 143, No. 4.
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abstract = "Purpose: To determine if corneal hysteresis (CH) was associated with increased central corneal thickness (CCT) induced by wearing soft contact lenses during eye closure. Design: A prospective laboratory investigation. Methods: CCT was measured with a modified optical coherence tomography (OCT), and CH was measured with a Reichert Ocular Response Analyzer (ORA) [Reichert Ophthalmic Instruments, Depew, New York, USA]. The ORA also determined values for intraocular pressure (IOP), corneal compensated IOP (IOPcc), and corneal resistance factor (CRF). One randomly selected eye of 20 non-contact lens wearers (four males and 16 females, age 19.7 ± 1.1 years) was patched during three hours of soft contact lens wear. Measurements were made before lens insertion, immediately upon removal, and every 20 minutes thereafter for 100 minutes. Results: Immediately after contact lens removal, CCT was increased by 13.1 ± 2.2{\%} (mean ± SD) compared with baseline (post hoc, P = .001). After 100 minutes, it remained elevated by 2.4 ± 1.6{\%} (post hoc, P = .001). However, there were no significant differences of CH at any time after lens wear (analysis of variance [ANOVA], P = .9). Immediately after lens removal, there were significant increases in IOP (post hoc, P = .003) and corneal resistance factor (CRF) (post-hoc, P = .015), but not in IOPcc (post hoc, P = .07). After lens wear, there were significant but weak correlations between the percentage change of CCT (CCT{\%}) and IOP (r = 0.32, P = .001) and IOPcc (r = 0.29, P = .001). However, there was no significant correlation between CCT{\%} and CH (r = 0.07, P = .458). Conclusion: CH as measured by ORA was not associated with corneal swelling induced by soft contact lens wear in this study group.",
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AU - Lu, Fan

AU - Xu, Suzhong

AU - Qu, Jia

AU - Shen, Meixiao

AU - Wang, Xiaoxing

AU - Fang, Haizhen

AU - Wang, Jianhua

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N2 - Purpose: To determine if corneal hysteresis (CH) was associated with increased central corneal thickness (CCT) induced by wearing soft contact lenses during eye closure. Design: A prospective laboratory investigation. Methods: CCT was measured with a modified optical coherence tomography (OCT), and CH was measured with a Reichert Ocular Response Analyzer (ORA) [Reichert Ophthalmic Instruments, Depew, New York, USA]. The ORA also determined values for intraocular pressure (IOP), corneal compensated IOP (IOPcc), and corneal resistance factor (CRF). One randomly selected eye of 20 non-contact lens wearers (four males and 16 females, age 19.7 ± 1.1 years) was patched during three hours of soft contact lens wear. Measurements were made before lens insertion, immediately upon removal, and every 20 minutes thereafter for 100 minutes. Results: Immediately after contact lens removal, CCT was increased by 13.1 ± 2.2% (mean ± SD) compared with baseline (post hoc, P = .001). After 100 minutes, it remained elevated by 2.4 ± 1.6% (post hoc, P = .001). However, there were no significant differences of CH at any time after lens wear (analysis of variance [ANOVA], P = .9). Immediately after lens removal, there were significant increases in IOP (post hoc, P = .003) and corneal resistance factor (CRF) (post-hoc, P = .015), but not in IOPcc (post hoc, P = .07). After lens wear, there were significant but weak correlations between the percentage change of CCT (CCT%) and IOP (r = 0.32, P = .001) and IOPcc (r = 0.29, P = .001). However, there was no significant correlation between CCT% and CH (r = 0.07, P = .458). Conclusion: CH as measured by ORA was not associated with corneal swelling induced by soft contact lens wear in this study group.

AB - Purpose: To determine if corneal hysteresis (CH) was associated with increased central corneal thickness (CCT) induced by wearing soft contact lenses during eye closure. Design: A prospective laboratory investigation. Methods: CCT was measured with a modified optical coherence tomography (OCT), and CH was measured with a Reichert Ocular Response Analyzer (ORA) [Reichert Ophthalmic Instruments, Depew, New York, USA]. The ORA also determined values for intraocular pressure (IOP), corneal compensated IOP (IOPcc), and corneal resistance factor (CRF). One randomly selected eye of 20 non-contact lens wearers (four males and 16 females, age 19.7 ± 1.1 years) was patched during three hours of soft contact lens wear. Measurements were made before lens insertion, immediately upon removal, and every 20 minutes thereafter for 100 minutes. Results: Immediately after contact lens removal, CCT was increased by 13.1 ± 2.2% (mean ± SD) compared with baseline (post hoc, P = .001). After 100 minutes, it remained elevated by 2.4 ± 1.6% (post hoc, P = .001). However, there were no significant differences of CH at any time after lens wear (analysis of variance [ANOVA], P = .9). Immediately after lens removal, there were significant increases in IOP (post hoc, P = .003) and corneal resistance factor (CRF) (post-hoc, P = .015), but not in IOPcc (post hoc, P = .07). After lens wear, there were significant but weak correlations between the percentage change of CCT (CCT%) and IOP (r = 0.32, P = .001) and IOPcc (r = 0.29, P = .001). However, there was no significant correlation between CCT% and CH (r = 0.07, P = .458). Conclusion: CH as measured by ORA was not associated with corneal swelling induced by soft contact lens wear in this study group.

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