Central basis of muscle fatigue in chronic fatigue syndrome

A. Kent-Braun, Khema R Sharma, M. W. Weiner, B. Massie, R. G. Miller

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

We studied whether muscle fatigue, metabolism, or activation are abnormal in the chronic fatigue syndrome (CFS). Subjects performed both an intermittent submaximal and a sustained maximal voluntary isometric exercise protocol of the tibialis anterior muscle. The extent of fatigue, metabolic response, and changes in both M-wave amplitude and twitch tension during exercise were similar in patients and controls. The response to systemic exercise was also normal in the patients. However, voluntary activation of the tibialis was significantly lower in the patients during maximal sustained exercise. The results indicate that patients with CFS have (1) normal fatigability and metabolism at both the intracellular and systemic levels, (2) normal muscle membrane function and excitation-contraction coupling, and (3) an inability to fully activate skeletal muscle during intense, sustained exercise. This failure of activation was well in excess of that found in controls, suggesting an important central component of muscle fatigue in CFS.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalNeurology
Volume43
Issue number1
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Chronic Fatigue Syndrome
Muscle Fatigue
Exercise
Excitation Contraction Coupling
Muscles
Fatigue
Skeletal Muscle
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kent-Braun, A., Sharma, K. R., Weiner, M. W., Massie, B., & Miller, R. G. (1993). Central basis of muscle fatigue in chronic fatigue syndrome. Neurology, 43(1), 125-131.

Central basis of muscle fatigue in chronic fatigue syndrome. / Kent-Braun, A.; Sharma, Khema R; Weiner, M. W.; Massie, B.; Miller, R. G.

In: Neurology, Vol. 43, No. 1, 01.01.1993, p. 125-131.

Research output: Contribution to journalArticle

Kent-Braun, A, Sharma, KR, Weiner, MW, Massie, B & Miller, RG 1993, 'Central basis of muscle fatigue in chronic fatigue syndrome', Neurology, vol. 43, no. 1, pp. 125-131.
Kent-Braun A, Sharma KR, Weiner MW, Massie B, Miller RG. Central basis of muscle fatigue in chronic fatigue syndrome. Neurology. 1993 Jan 1;43(1):125-131.
Kent-Braun, A. ; Sharma, Khema R ; Weiner, M. W. ; Massie, B. ; Miller, R. G. / Central basis of muscle fatigue in chronic fatigue syndrome. In: Neurology. 1993 ; Vol. 43, No. 1. pp. 125-131.
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