Cellular responses to whitlockite

L. M. Ryan, Herman S Cheung, R. Z. LeGeros, I. V. Kurup, J. Toth, P. R. Westfall, G. M. McCarthy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Whitlockite crystals have been observed in both degenerating and normal articular cartilages. To determine their potential for inducing cartilage degeneration, we studied their ability to induce mitogenesis and synthesis and secretion of metalloproteases in vitro. Whitlockite crystals were found to stimulate cell proliferation and to stimulate synthesis and secretion of stromelysin and collagenase. However, they were less stimulatory than crystals that contained calcium (Ca) and phosphate without magnesium substitution for Ca. Whitlockite crystals elicit biologic cellular responses that suggest potential pathogenicity in arthritis, but are less potent than Ca phosphate crystals without magnesium.

Original languageEnglish
Pages (from-to)374-377
Number of pages4
JournalCalcified Tissue International
Volume65
Issue number5
DOIs
StatePublished - Nov 12 1999

Fingerprint

Matrix Metalloproteinase 3
Articular Cartilage
Metalloproteases
Collagenases
Magnesium
Arthritis
Cartilage
Virulence
Cell Proliferation
whitlockite
calcium magnesium phosphate
In Vitro Techniques
calcium phosphate

Keywords

  • Metalloprotease
  • Mitogenesis
  • Whitlockite

ASJC Scopus subject areas

  • Endocrinology

Cite this

Ryan, L. M., Cheung, H. S., LeGeros, R. Z., Kurup, I. V., Toth, J., Westfall, P. R., & McCarthy, G. M. (1999). Cellular responses to whitlockite. Calcified Tissue International, 65(5), 374-377. https://doi.org/10.1007/s002239900716

Cellular responses to whitlockite. / Ryan, L. M.; Cheung, Herman S; LeGeros, R. Z.; Kurup, I. V.; Toth, J.; Westfall, P. R.; McCarthy, G. M.

In: Calcified Tissue International, Vol. 65, No. 5, 12.11.1999, p. 374-377.

Research output: Contribution to journalArticle

Ryan, LM, Cheung, HS, LeGeros, RZ, Kurup, IV, Toth, J, Westfall, PR & McCarthy, GM 1999, 'Cellular responses to whitlockite', Calcified Tissue International, vol. 65, no. 5, pp. 374-377. https://doi.org/10.1007/s002239900716
Ryan LM, Cheung HS, LeGeros RZ, Kurup IV, Toth J, Westfall PR et al. Cellular responses to whitlockite. Calcified Tissue International. 1999 Nov 12;65(5):374-377. https://doi.org/10.1007/s002239900716
Ryan, L. M. ; Cheung, Herman S ; LeGeros, R. Z. ; Kurup, I. V. ; Toth, J. ; Westfall, P. R. ; McCarthy, G. M. / Cellular responses to whitlockite. In: Calcified Tissue International. 1999 ; Vol. 65, No. 5. pp. 374-377.
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