Cellular repair strategies for spinal cord injury

Damien D Pearse, David J. Barakat

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The implantation of exogenous cells or tissues has been a popular and successful strategy to overcome physical discontinuity and support axon growth in experimental models of spinal cord injury (SCI). Cellular therapies exhibit a multifarious potential for SCI restoration, providing not only a supportive substrate upon which axons can traverse the injury site, but also reducing progressive tissue damage and scarring, facilitating remyelination repair, and acting as a source for replacing and re-establishing lost neural tissue and its circuitry. The past two decades of research into cell therapies for SCI repair have seen the progressive evolution from whole tissue strategies, such as peripheral nerve grafts, to the use of specific, purified cell types from a diverse range of sources and, recently, to the employment of stem or neural precursor cell populations that have the potential to form a full complement of neural cell types. Although the progression of cell therapies from laboratory to clinical implementation has been slow, human SCI safety and efficacy trials involving several cell types within the US appear to be close at hand.

Original languageEnglish
Pages (from-to)639-652
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Spinal Cord Injuries
Repair
Tissue
Cell- and Tissue-Based Therapy
Cells
Axons
Spinal Cord Regeneration
Grafts
Restoration
Peripheral Nerves
Cicatrix
Theoretical Models
Transplants
Substrates
Safety
Wounds and Injuries
Growth
Research
Population
Therapeutics

Keywords

  • Bone marrow stromal cells
  • Graft
  • Macrophage
  • Neurotrophin
  • Olfactory ensheathing cells
  • Stem cells
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

Cite this

Cellular repair strategies for spinal cord injury. / Pearse, Damien D; Barakat, David J.

In: Expert Opinion on Biological Therapy, Vol. 6, No. 7, 01.07.2006, p. 639-652.

Research output: Contribution to journalArticle

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