Cellular proliferation in female pelvic organ prolapse: A pilot study

Peter Takacs, Cristina Saiz, Sindy Jaramillo, Yanping Zhang, Sujata Yavagal, Keith A Candiotti, Carlos Medina

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To assess cell proliferation in pelvic organ prolapse (POP). Methods: Tissue samples of the anterior vaginal wall and uterosacral ligaments (USLs) were obtained from eight women with combined anterior vaginal wall and uterine prolapse and from eight women without POP in a standardized fashion. Immunohistochemistry against Ki-67 was used to assess cell proliferation in vaginal and USL biopsies. Results: There were no significant differences in age, parity, menopausal status or hormone replacement therapy between the two groups. The POP-Q stage of uterine and anterior vaginal wall prolapse was significantly higher in the group of women with prolapse compared to the group without prolapse [median (range) 3 (3-4) vs. 0 (0), <0.01]. There was no significant difference between Ki-67 expressions in women with or without prolapse. Conclusion: There were no significant differences in cell proliferation between samples from women with or without POP.

Original languageEnglish
Pages (from-to)1329-1332
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume283
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Pelvic Organ Prolapse
Uterine Prolapse
Cell Proliferation
Prolapse
Ligaments
Hormone Replacement Therapy
Parity
Immunohistochemistry
Biopsy

Keywords

  • Cell proliferation
  • Cystocele
  • Prolapse
  • Smooth muscle

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Cellular proliferation in female pelvic organ prolapse : A pilot study. / Takacs, Peter; Saiz, Cristina; Jaramillo, Sindy; Zhang, Yanping; Yavagal, Sujata; Candiotti, Keith A; Medina, Carlos.

In: Archives of Gynecology and Obstetrics, Vol. 283, No. 6, 01.06.2011, p. 1329-1332.

Research output: Contribution to journalArticle

Takacs, Peter ; Saiz, Cristina ; Jaramillo, Sindy ; Zhang, Yanping ; Yavagal, Sujata ; Candiotti, Keith A ; Medina, Carlos. / Cellular proliferation in female pelvic organ prolapse : A pilot study. In: Archives of Gynecology and Obstetrics. 2011 ; Vol. 283, No. 6. pp. 1329-1332.
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