Cellular immunology in HIV-1 positive African American women using alcohol and cocaine

Francesco Chiappelli, Paul Shapshak, Fariba Younai, Clyde McCoy, Bryan Page, Paolo Prolo

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Co-use of illicit drugs, in particular cocaine and alcohol, is common among HIV-1+ men and women of different ethnic groups. We compared cohorts of alcohol and cocaine co-users HIV-1+ African American women and in cohorts of drug-free, or methamphetamine users HIV-1+ men. We monitored clinical cellular immune parameters at repeated regular intervals. We found that significant inverse correlations between CD8+CD38+ cells and subpopulations of CD4+ cells distinguished by the expression of CD45RA in HIV-1+ alcohol and cocaine co-users but not in drug-free HIV-1+ patients. Following stratification for CD4+ cell number, we found the CD4+CD45RA+ subpopulation to be significantly higher (p<0.05) in the drug user compared to drug-free HIV-1+. Drug abuse may alter the change from the CD4+CD45RA+ to the CD4+CD45RA- phenotype selectively, which recovers in HIV-1+ methamphetamine abusers during treatment from baseline to 4-weeks, as manifested by improved IL-2 production in vitro, of TH1 and TH2 cytokines during progression to AIDS.

Original languageEnglish (US)
Pages (from-to)2434-2441
Number of pages8
JournalFrontiers in Bioscience
Volume11
Issue numberSUPPL. 2
DOIs
StatePublished - Jun 6 2006

Keywords

  • CD4+,CD45ra+,CD4+CD45RA
  • Cocaethylene
  • Cocaine
  • HIV-1 seropositive
  • Immunopathology
  • Methamphetamine
  • Phenotype

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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