Abstract
Co-use of illicit drugs, in particular cocaine and alcohol, is common among HIV-1+ men and women of different ethnic groups. We compared cohorts of alcohol and cocaine co-users HIV-1+ African American women and in cohorts of drug-free, or methamphetamine users HIV-1+ men. We monitored clinical cellular immune parameters at repeated regular intervals. We found that significant inverse correlations between CD8+CD38+ cells and subpopulations of CD4+ cells distinguished by the expression of CD45RA in HIV-1+ alcohol and cocaine co-users but not in drug-free HIV-1+ patients. Following stratification for CD4+ cell number, we found the CD4+CD45RA+ subpopulation to be significantly higher (p<0.05) in the drug user compared to drug-free HIV-1+. Drug abuse may alter the change from the CD4+CD45RA+ to the CD4+CD45RA- phenotype selectively, which recovers in HIV-1+ methamphetamine abusers during treatment from baseline to 4-weeks, as manifested by improved IL-2 production in vitro, of TH1 and TH2 cytokines during progression to AIDS.
Original language | English (US) |
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Pages (from-to) | 2434-2441 |
Number of pages | 8 |
Journal | Frontiers in Bioscience |
Volume | 11 |
Issue number | SUPPL. 2 |
DOIs | |
State | Published - 2006 |
Keywords
- CD4+,CD45ra+,CD4+CD45RA
- Cocaethylene
- Cocaine
- HIV-1 seropositive
- Immunopathology
- Methamphetamine
- Phenotype
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology