Abstract
Co-use of illicit drugs, in particular cocaine and alcohol, is common among HIV-1+ men and women of different ethnic groups. We compared cohorts of alcohol and cocaine co-users HIV-1+ African American women and in cohorts of drug-free, or methamphetamine users HIV-1+ men. We monitored clinical cellular immune parameters at repeated regular intervals. We found that significant inverse correlations between CD8+CD38+ cells and subpopulations of CD4+ cells distinguished by the expression of CD45RA in HIV-1+ alcohol and cocaine co-users but not in drug-free HIV-1+ patients. Following stratification for CD4+ cell number, we found the CD4+CD45RA+ subpopulation to be significantly higher (p<0.05) in the drug user compared to drug-free HIV-1+. Drug abuse may alter the change from the CD4+CD45RA+ to the CD4+CD45RA- phenotype selectively, which recovers in HIV-1+ methamphetamine abusers during treatment from baseline to 4-weeks, as manifested by improved IL-2 production in vitro, of TH1 and TH2 cytokines during progression to AIDS.
| Original language | English |
|---|---|
| Pages (from-to) | 2434-2441 |
| Number of pages | 8 |
| Journal | Frontiers in Bioscience |
| Volume | 11 |
| Issue number | SUPPL. 2 |
| DOIs | |
| State | Published - Jun 6 2006 |
Fingerprint
Keywords
- CD4+,CD45ra+,CD4+CD45RA
- Cocaethylene
- Cocaine
- HIV-1 seropositive
- Immunopathology
- Methamphetamine
- Phenotype
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry
- Cell Biology
Cite this
Cellular immunology in HIV-1 positive African American women using alcohol and cocaine. / Chiappelli, Francesco; Shapshak, Paul; Younai, Fariba; McCoy, Clyde B; Page, John; Prolo, Paolo.
In: Frontiers in Bioscience, Vol. 11, No. SUPPL. 2, 06.06.2006, p. 2434-2441.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cellular immunology in HIV-1 positive African American women using alcohol and cocaine
AU - Chiappelli, Francesco
AU - Shapshak, Paul
AU - Younai, Fariba
AU - McCoy, Clyde B
AU - Page, John
AU - Prolo, Paolo
PY - 2006/6/6
Y1 - 2006/6/6
N2 - Co-use of illicit drugs, in particular cocaine and alcohol, is common among HIV-1+ men and women of different ethnic groups. We compared cohorts of alcohol and cocaine co-users HIV-1+ African American women and in cohorts of drug-free, or methamphetamine users HIV-1+ men. We monitored clinical cellular immune parameters at repeated regular intervals. We found that significant inverse correlations between CD8+CD38+ cells and subpopulations of CD4+ cells distinguished by the expression of CD45RA in HIV-1+ alcohol and cocaine co-users but not in drug-free HIV-1+ patients. Following stratification for CD4+ cell number, we found the CD4+CD45RA+ subpopulation to be significantly higher (p<0.05) in the drug user compared to drug-free HIV-1+. Drug abuse may alter the change from the CD4+CD45RA+ to the CD4+CD45RA- phenotype selectively, which recovers in HIV-1+ methamphetamine abusers during treatment from baseline to 4-weeks, as manifested by improved IL-2 production in vitro, of TH1 and TH2 cytokines during progression to AIDS.
AB - Co-use of illicit drugs, in particular cocaine and alcohol, is common among HIV-1+ men and women of different ethnic groups. We compared cohorts of alcohol and cocaine co-users HIV-1+ African American women and in cohorts of drug-free, or methamphetamine users HIV-1+ men. We monitored clinical cellular immune parameters at repeated regular intervals. We found that significant inverse correlations between CD8+CD38+ cells and subpopulations of CD4+ cells distinguished by the expression of CD45RA in HIV-1+ alcohol and cocaine co-users but not in drug-free HIV-1+ patients. Following stratification for CD4+ cell number, we found the CD4+CD45RA+ subpopulation to be significantly higher (p<0.05) in the drug user compared to drug-free HIV-1+. Drug abuse may alter the change from the CD4+CD45RA+ to the CD4+CD45RA- phenotype selectively, which recovers in HIV-1+ methamphetamine abusers during treatment from baseline to 4-weeks, as manifested by improved IL-2 production in vitro, of TH1 and TH2 cytokines during progression to AIDS.
KW - CD4+,CD45ra+,CD4+CD45RA
KW - Cocaethylene
KW - Cocaine
KW - HIV-1 seropositive
KW - Immunopathology
KW - Methamphetamine
KW - Phenotype
UR - http://www.scopus.com/inward/record.url?scp=33744460738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744460738&partnerID=8YFLogxK
U2 - 10.2741/1981
DO - 10.2741/1981
M3 - Article
C2 - 16720325
AN - SCOPUS:33744460738
VL - 11
SP - 2434
EP - 2441
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
SN - 1093-9946
IS - SUPPL. 2
ER -